Results 201 to 210 of about 948,748 (269)

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Corrigendum to: Molecular identification of severe fever with thrombocytopenia syndrome virus in deer ked: implications for disease transmission (One Health, volume 21, article number 101107). [PDF]

One Health
Casel MAB, Choi JH, Jang H, Jang SG, Gil J, Rollon R, Cheun SY, Choi I, Kim EH, Kim YI, Choi YK.   +10 more
europepmc   +1 more source

Piezo2 Mediates a Vicious Cycle of “Mechanical Homeostasis Imbalance—Inflammation” in Sensory Nerves and the Cartilage Endplate

Advanced Science, EarlyView.
In a lumbar spine instability model, dorsal root ganglion cells mediate the perception of relevant mechanical stresses through Piezo2 and subsequently release CGRP. CGRP activates the NF‐κB signaling pathway in cartilage endplate cells through the receptor RAMP1.
Hanpeng Xu, Wen Geng, Zhi Du, Yifan Du, Di Wu, Bide Tong, Huaizhen Liang, Xingyu Zhou, Zixuan Ou, Junyu Wei, Kun Wang, Yu Song, Wenbin Hua, Yan Xu, Wencan Ke, Bingjin Wang, Cao Yang   +16 more
wiley   +1 more source

A comprehensive method on black-legged tick larvae and nymph feeding on mice to study Lyme disease transmission and acquisition. [PDF]

Front Microbiol
Scholl A, Li B, Dennis J, De S.
europepmc   +1 more source

QBP1 Peptide as a Potential Anti‐Amyloidogenic Therapy for Type 2 Diabetes: An In Vitro Study

Advanced Science, EarlyView.
The anti‐amyloidogenic peptide QBP1 effectively halts human islet amyloid polypeptide (hIAPP) aggregation, preventing the formation of toxic β‐structured intermediates. Through a combination of biophysical assays, molecular dynamics, and cell‐based studies, QBP1 is shown to preserve β‐cell viability and metabolic homeostasis, positioning it as a ...
María M. Tejero‐Ojeda, Ada Bernaus Vives, Michał Wojciechowski, Dinh Quoc Huy Pham, Mateusz Chwastyk, Mario Vallejo, Anna Novials, Douglas V. Laurents, Mariano Carrión‐Vázquez   +8 more
wiley   +1 more source

A beta-Poisson model for infectious disease transmission. [PDF]

PLoS Comput Biol
Hilton J, Hall I.
europepmc   +1 more source

SIRE 2.0: a novel method for estimating polygenic host effects underlying infectious disease transmission, and analytical expressions for prediction accuracies. [PDF]

Genet Sel Evol
Pooley CM, Marion G, Prentice J, Pong-Wong R, Bishop SC, Doeschl-Wilson A.   +5 more
europepmc   +1 more source

Knowledge, Attitudes, and Practices of the Saudi Arabian Population Regarding Contaminated Banknotes: Implications for Infectious Disease Transmission and Analyzing the Biofilm in Wallet as a Reservoir. [PDF]

Can J Infect Dis Med Microbiol
Almogbel M, Huq M, Almogbel M, Almatroudi A, Allemailem KS.   +4 more
europepmc   +1 more source

Den Use Patterns of Endangered San Joaquin Kit Foxes in Urban Environments May Facilitate Disease Transmission. [PDF]

Animals (Basel)
Cypher BL, Gabaldon A, Kelly EC, Westall TL, Deatherage NA.   +4 more
europepmc   +1 more source

Modelling COVID-19 mutant dynamics: understanding the interplay between viral evolution and disease transmission dynamics. [PDF]

R Soc Open Sci
Saldaña F, Stollenwerk N, Aguiar M.
europepmc   +1 more source