Results 231 to 240 of about 7,199,284 (318)

An integrated framework for modelling respiratory disease transmission and designing surveillance networks using a sentinel index. [PDF]

R Soc Open Sci
Borges DGF, Coutinho ER, Jorge DCP, Barreto ME, Ramos PIP, Barral-Netto M, Coutinho ALGA, Landau L, Pinho STR, Andrade RFS.   +9 more
europepmc   +1 more source

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source

Isolation of toxigenic <i>Corynebacterium diphtheriae</i> from cutaneous lesions in a donkey in Ontario, Canada, 2024: Implications for zoonotic disease transmission and One Health approach. [PDF]

Can Commun Dis Rep
Okechukwu C, Rebellato S, Pitfield H, Magnusson K, Sereshk R, Slavic D, McClinchey H, Wilson S, Kus J, Lee C.   +9 more
europepmc   +1 more source

A Soft, Flexible Implant for Wireless Photothermal–Pyroelectric Neurostimulation

Advanced Science, EarlyView.
A replication strategy is used to enlarge the exposed surface area of barium titanate within flexible films with embedded carbon nanotubes, enabling efficient photothermal‐pyroelectric stimulation. Polar crystalline nanosheets show superior performance in guiding neural progenitor cells toward neuronal differentiation.
Jiang Wu, Minmin Mao, Beltzane Garcia Cirera, Hao Ye, Xiangzhong Chen, Josep Puigmartí‐Luis, Ni Qin, Salvador Pané   +7 more
wiley   +1 more source

The chemosensory world of mosquitoes: olfactory receptors and their role in blocking mosquito-borne disease transmission. [PDF]

Parasit Vectors
Xiong S, Liang J, Gao S, Liu Z, Zheng H, Yang X, Wang Y, Yu S.   +7 more
europepmc   +1 more source

BAP31 Drives Cartilage Calcification through Disruption of Autophagosome–Lysosome Fusion in Osteoarthritis

Advanced Science, EarlyView.
Mechanical stress activates BAP31 in chondrocytes. BAP31 competes with ATG14 for binding to STX17, disrupting the STX17–ATG14 complex required for autophagosome–lysosome fusion. The resultant autophagic flux blockade drives the generation of autophagy‐derived exosomes, which mediate pathological cartilage calcification in OA. Chondrocyte‐targeted BAP31
Zhi‐hua Xu, Ruo‐xin Wang, Feng He, Qian Liu, Fu‐yin Li, Min Hui, Yu‐qian Shi, Yu Jiang, Qing‐hua Li, Jun‐wen Jing, Shi‐bin Yu, Li‐tian Ma, Qian‐nan Niu, Mian Zhang   +13 more
wiley   +1 more source

Characterizing social behavior relevant for infectious disease transmission in four low- and middle-income countries, 2021-2023. [PDF]

Nat Commun
Nelson KN, Kiti MC, Shiiba M, Sacoor C, Bardají A, Macicame I, Jamisse E, Tchavana C, José A, Cavele N, Maldonado H, Jarquin C, Ajsivinac HM, Raghava V, Samuel P, Srinivasan R, Kazi M, Allana R, Kim SS, Prasad PV, Chen D, Liu C, Jenness SM, Ahmed N, Aguolu O, Sundaram MA, Yildirim I, Malik F, Melegaro A, Lopman BA, Omer SB.   +30 more
europepmc   +1 more source

A Review on Catalytic Nanostructured Electrodes for Wearable and Implantable Abiotic Glucose Fuel Cells

Advanced Science, EarlyView.
This review identifies current and future directions in abiotic nanostructured catalysts to develop reliable and sustainable glucose fuel cells to power the next generation of bioelectronic devices. ABSTRACT The global rise in incidence of chronic diseases has led to the demand for innovative solutions that help patients manage their conditions with ...
Asghar Niyazi, Hannah S. Leese, Benjamin Metcalfe, Mirella Di Lorenzo   +3 more
wiley   +1 more source

A New Approach for Respiratory Droplet Trajectory: Implications for Viral and Bacterial Disease Transmission in Emergency Departments. [PDF]

Yonago Acta Med
Aydin IE, Aydin B, Aydin Savas S, Aydin M.   +3 more
europepmc   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source