Results 171 to 180 of about 5,463,122 (264)

In Focus: Vector‐borne disease [PDF]

Pest Management Science, 2007
openaire   +2 more sources

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

MaxEnt modeling and risk evaluation of chagas disease vectors in the domestic cycle of Hidalgo, Mexico. [PDF]

PLoS Negl Trop Dis
Chico-Avelino M, Ramos-Frías J, López-Mejía A, Martínez-Calvillo S, Manning-Cela RG.   +4 more
europepmc   +1 more source

Disregarding reservoirs of disease vectors: A surveillance paradox in Africa. [PDF]

EClinicalMedicine, 2020
Chanda E.
europepmc   +1 more source

Deep Contrastive Learning for High‐Throughput Prediction of Drug Resistance Mutations from Sequences

Advanced Science, EarlyView.
This study presents DeepMutDTA, a deep learning framework aimed at predicting mutation‐induced changes in protein‐drug interactions and prioritizing variants potentially linked to drug resistance. Trained on large‐scale data, it incorporates SimSiam‐MuTF, a label‐aware contrastive fine‐tuning strategy that encourages separation between WT and MT ...
Xiaowen Hu, Pan Zhang, Shangqian Wu, Hao Sun, Minwei Li, Sophia Tsoka, Zizhang Sheng, Lei Deng   +7 more
wiley   +1 more source

Omics Tools Applied to the Study of Chagas Disease Vectors: Proteomics and Metabolomics. [PDF]

Am J Trop Med Hyg
Borsatto KC, Coronado MA, Galvão C, Arni RK, Chaboli Alevi KC.   +4 more
europepmc   +1 more source

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Advanced Science, EarlyView.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Ziwei Wang, Wendai Bao, Ke Shui, Jun Qin, Jun Chen, Min Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong   +17 more
wiley   +1 more source

Putting behaviors into context for vector-borne diseases: Examining behaviors that may reduce exposure to disease vectors. [PDF]

PLoS Negl Trop Dis
de Brito RN, Tanner S, Runk JV, Gottdenker NL, Reina A, Rodríguez A, Rigg C, Mendieta D, Schmidt JP, Hoyos J, González K, Archbold K, Hall RJ, Gómez T, Pineda V, Vásquez V, Calzada JE, Saldaña A.   +17 more
europepmc   +1 more source

Compensatory Mitophagy via NEDD4/HIF‐1α/BNIP3 Pathway Restrains EndMT and Renal Allograft Interstitial Fibrosis Induced by TNFα

Advanced Science, EarlyView.
The role of TNFα in the process of renal allograft interstitial fibrosis is complex and multifaceted. As it can promote renal allograft interstitial fibrosis by inducing mitochondrial dysfunction and EndMT, and also mediating compensatory mitophagy through the NEDD4–HIF‐1α–BNIP3 pathway, which clears damaged mitochondria and inhibits EndMT, thereby ...
Dengyuan Feng, Qinghuan Shen, Junqi Zhang, Jiawen Liu, Zeping Gui, Zijie Wang, Qianguang Han, Shuang Fei, Hao Chen, Li Sun, Jun Tao, Zhijian Han, Xiaobing Ju, Min Gu, Jianjian Zhang, Ruoyun Tan   +15 more
wiley   +1 more source

Diversity and spatiotemporal distribution of mosquitoes (Diptera: Culicidae) with emphasis on disease vectors across agroecological areas of Kerala, India. [PDF]

Sci Rep
Mathiarasan L, Natarajan R, Aswin A, Justin NAJA, Thampi N, Kumari M, Priya GSL, Rohini PD, Gopalakrishnan S, Jambulingam P, Eapen A.   +10 more
europepmc   +1 more source