Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Correction: In Silico Repositioning-Chemogenomics Strategy Identifies New Drugs with Potential Activity against Multiple Life Stages of Schistosoma mansoni. [PDF]
PLoS Neglected Tropical Diseases, 2015 PLOS Neglected Tropical Diseases Staff
doaj +1 more source
Atherogenic index of plasma and coronary artery disease: a systematic review and meta-analysis of observational studies [PDF]
Ramin Assempoor +6 more
openalex +1 more source
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
Correction: Buruli Ulcer in Cameroon: The Development and Impact of the National Control Programme. [PDF]
PLoS Neglected Tropical Diseases, 2016 PLOS Neglected Tropical Diseases Staff
doaj +1 more source
Molecular Oncology, EarlyView.Using multi‐omic characterization, we aimed to identify key regulators specific to squamous cell lung carcinoma (SqCC). SqCC‐specific differentially expressed genes were integrated with metabolics data. High expression of the creatine transporter SLC6A8, along with elevated creatine levels, appeared to be a distinct metabolic feature of SqCC.
Johan Staaf +10 more
wiley +1 more source
Risk stratification and healthcare disparities in COVID-19 outcomes: a retrospective cohort study of treatment pathways before and after infection. [PDF]
BMC Infect DisJiang X, Wei Y, Li J, Wang S, Wang R.
europepmc +1 more source
Molecular Oncology, EarlyView.Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser +14 more
wiley +1 more source
Correction: Pyrethroid Treatment of Cattle for Tsetse Control: Reducing Its Impact on Dung Fauna. [PDF]
PLoS Neglected Tropical Diseases, 2015 PLOS Neglected Tropical Diseases Staff
doaj +1 more source
Improving self‐management in adolescents with sickle cell disease
, 2020 Lori E. Crosby +7 more
openalex +2 more sources