Contributions to the mathematical theory of epidemics IV. Analysis of experimental epidemics of the virus disease mouse ectromelia [PDF]
W. O. Kermack, A. G. McKendrick
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Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed+8 more
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Enhancing regional disease burden estimates: insights from the comparison of Global Burden of Disease and China's notifiable infectious diseases data with policy implications (2010-2020). [PDF]
Zhao ZY+8 more
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Anomalies of the encephalic arteries among the insane. A study of the arteries at the base of the encephallon in two hundred and twenty consecutive cases of mental disease, with special reference to anomalies of the circle of Willis [PDF]
I. W. Blackburn
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Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho+11 more
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Exploring the common genetic basis of metabolic syndrome-related diseases and chronic kidney disease: insights from extensive genome-wide cross-trait analyses. [PDF]
Yin Y+6 more
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Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski+19 more
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Spectrum and epidemiology of rare diseases in a Chinese natural population of 14.31 million residents, 2012-2023. [PDF]
Li MJ+8 more
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