Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Expert-Designed Fact Sheets and AI-Based Analysis of Patient Symptoms to Combat Diagnostic Delays in Inherited Metabolic Diseases. [PDF]
J Inherit Metab DisCano A +25 more
europepmc +1 more source
Preimplantation genetic testing for polygenic diseases: A novel paradigm in embryo selection. [PDF]
Biochem Biophys RepJing T, Du Y.
europepmc +1 more source
The Student Voice Prize: ten years of learning from healthcare students. [PDF]
Orphanet J Rare DisMcKay L, Thompson R.
europepmc +1 more source
mRNA vaccines and therapeutics beyond COVID-19: A review of the global clinical development landscape, low- and middle-income countries involvement and relevance to their contexts. [PDF]
Hum Vaccin ImmunotherMoschioni M +8 more
europepmc +1 more source
Risk of Noncommunicable Diseases After Hospitalization for Community-Acquired Pneumonia. [PDF]
Open Forum Infect DisRamirez J +4 more
europepmc +1 more source
Correction to: Relationship Between Cytokine Level and Viral Load in Severe Fever with Thrombocytopenia Syndrome. [PDF]
Open Forum Infect Diseuropepmc +1 more source