Results 151 to 160 of about 157,074 (374)

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

open access: yesMolecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova   +18 more
wiley   +1 more source

Neurological impairment of the monozygotic twins with congenital infection presumed by Zika virus: Case report

open access: yesRevista Brasileira de Saúde Materno Infantil
Introduction: the increase in the incidence of congenital microcephaly in Brazil has been associated to the Zika virus outbreak. This case report aimed to describe the neurological impairment of monozygotic twins presumably due to an intrauterine ...
Ana Karina Rocha Hora Mendonça   +1 more
doaj   +1 more source

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

open access: yesMolecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma   +9 more
wiley   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

A study of diabetes mellitus within a large sample of Australian twins. [PDF]

open access: yes, 2008
David L. Duffy   +9 more
core   +1 more source

A ribbon of twins for extracting vessel boundaries [PDF]

open access: yes, 2005
This paper presents an efficient model for automatic detection and extraction of blood vessels in ocular fundus images. The model is formed using a combination of the concept of ribbon snakes and twin snakes.
Al-Diri, Bashir, Hunter, Andrew
core  

A multidisciplinary approach towards modeling of a virtual human lung

open access: yesnpj Systems Biology and Applications
Integrating biological data with in silico modeling offers the transformative potential to develop virtual human models, or “digital twins.” These models hold immense promise for deepening our understanding of diseases and uncovering new therapeutic ...
Timothy Lam   +4 more
doaj   +1 more source

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