Results 191 to 200 of about 45,703 (295)

Evidence for a Major Role of Heredity in Graves’ Disease: A Population-Based Study of Two Danish Twin Cohorts¹ [PDF]

, 2001
Thomas Heiberg Brix, Kirsten Ohm Kyvik, Kaare Christensen, László Hegedüs   +3 more
openalex   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Low PAPP-A Levels and Growth in Twin Pregnancies. [PDF]

Life (Basel)
Sapantzoglou I, Papageorgiou D, Kontopoulou AM, Karasmani C, Rouvali A, Pegkou A, Simou M, Pafilis I, Souka A, Theodora M, Antsaklis P, Daskalakis G.   +11 more
europepmc   +1 more source

Parkinson's disease in twins. [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 1987
openaire   +2 more sources

Assessment of exercise capacity over 6 months in identical twins with late-onset pompe disease, with and without enzyme replacement therapy [PDF]

, 2015
José Luís Muñoz-Blanco, I. Catalina-Álvarez, M.R. Jiménez-Bautista, Irene Bretón Lesmes, A. Traba-López   +4 more
openalex   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Associations Between 40-Year Trajectories of BMI and Proteomic and Epigenetic Aging Clocks: Deciphering Nonlinearity and Interactions. [PDF]

Aging Cell
Drouard G, Argentieri MA, Heikkinen A, Ollikainen M, Kaprio J.   +4 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

AI-Resolved Protein Energy Landscapes, Electrodynamics, and Fluidic Microcircuits as a Unified Framework for Predicting Neurodegeneration. [PDF]

Int J Mol Sci
Pantu C, Breazu A, Oprea S, Serban M, Covache-Busuioc RA, Munteanu O, Dobrin N, Costea D, Eva L.   +8 more
europepmc   +1 more source