Results 291 to 300 of about 2,696,673 (357)

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

Twin Phenomena of Hypertrophic Cardiomyopathy: A Reported Case Series. [PDF]

Anatol J Cardiol
Zeng JT, Zhang YA, Ma TY, Huang K, Lu SJ, Zhong JH, Li JJ.   +6 more
europepmc   +1 more source

Adenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study

FEBS Open Bio, EarlyView.
The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli, Andrea Spinaci, Cui Chang, Rosaria Volpini, Catia Lambertucci, Matteo Landriscina, Vincenza Conteduca, Consuelo Amantini, Cristina Aguzzi, Laura Zeppa, Martina Giangrossi, Laura Soverchia, Matteo Santoni, Massimo Nabissi, Giorgio Santoni, Carlo Polidori   +15 more
wiley   +1 more source

Optimizing metabolic health with digital twins. [PDF]

NPJ Aging
Su C, Wang P, Foo N, Ho D.
europepmc   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

Association of Polygenic Risk for Psychiatric Disorders with Cardiometabolic Disease

Bergstedt J, Kõiv K, Jangmo A, Haram M, Jaholkowski PP, Treur JL, Brikell I, Chang Z, Larsson H, Magnusson PKE, McIntosh AM, Lewis CM, Lee BK, Sønderby IE, Lu Y, Sullivan PF, Valdimarsdóttir UA, Estonian Biobank Research Team, Andreassen O, Tesli M, Lehto K, Fang F.   +21 more
europepmc   +1 more source

Challenges and opportunities for digital twins in precision medicine from a complex systems perspective. [PDF]

NPJ Digit Med
De Domenico M, Allegri L, Caldarelli G, d'Andrea V, Di Camillo B, Rocha LM, Rozum J, Sbarbati R, Zambelli F.   +8 more
europepmc   +1 more source

Downregulation of O‐GlcNAcylation enhances etoposide‐induced p53‐mediated apoptosis in HepG2 human liver cancer cells

FEBS Open Bio, EarlyView.
Etoposide, a topoisomerase II inhibitor, reduces O‐GlcNAcylation in HepG2 liver cancer cells. Further inhibition of O‐GlcNAc transferase by OSMI‐1 enhanced etoposide‐induced apoptosis, lowering the IC50 for viability and increasing the EC50 for cytotoxicity.
Jaehoon Lee, Gi‐Bang Koo, Jihye Park, Byung‐Cheol Han, Mijin Kwon, Seung‐Ho Lee   +5 more
wiley   +1 more source

An observational study of asymmetry in CMT1A [PDF]

, 2015
Carr, AS, Laura, M, Pelayo-Negro, AL, Reilly, MM, Skorupinska, M   +4 more
core  

Could digital twins be the next revolution in healthcare? [PDF]

Eur J Public Health
de Oliveira El-Warrak L, Miceli de Farias C.   +1 more
europepmc   +1 more source