Results 141 to 150 of about 409,458 (389)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Reverse impact of chordae tendineae structural changes on its biomechanical properties as a part of pathogenesis in canine myxomatous mitral valve disease

BMC Veterinary Research
Background Myxomatous mitral valve disease is the most common cardiac disease among dogs. The mitral valve consists of valve leaflets, chordae tendineae and papillary muscles.
Justyn Gach, Agnieszka Mackiewicz, Izabela Janus-Ziółkowska, Agnieszka Noszczyk-Nowak   +3 more
doaj   +1 more source

The Institute Report from the Veterinary Virus Research Institute [PDF]

, 1963
Topics in this Institute Report include: Message from the Director [James A. Baker]; Work in Cornell Research Laboratory for Diseases of Dogs; Work in Microbiology Laboratories; In Appreciation; Staff Activities; The John M. Olin Professorship (Leland E.
Baker, James A., Cornell University College of Veterinary Medicine. Veterinary Virus Research Institute   +1 more
core   +1 more source

Chagas Disease in Dogs [PDF]

Journal of Veterinary Healthcare, 2018
Chagas disease is zoonotic illness or an anthropozoonosis caused by flagellated protozoan parasite Trypanosoma cruzi. This infection presents alarming rates of incidence/prevalence, for this reason, is recognized worldwide as one of the 13 most neglected tropical diseases 1.
openaire   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

Molecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa, Julia Richert, Tomasz Stokowy, Alicja Staśczak, Mariusz Szajewski, Maciej Ciesielski, Petra M. Grešner, Bartłomiej Tomasik, Łukasz Arcimowicz, Agnieszka Stankiewicz, Grażyna Suchodolska, Elżbieta Senkus, Wiesław Kruszewski, Anna J. Żaczek, Aleksandra Markiewicz   +14 more
wiley   +1 more source

Case Report: Generalized motor tonic seizures characterized by paroxysmal fast activity on EEG in a Tonkinese cat

Frontiers in Veterinary Science
Epilepsy is one of the most common neurological disorders in cats, affecting 1%−2% of the feline population. Feline epilepsy can often be managed with standard anti-seizure medications, which typically offer moderate to good seizure control.
Laura Brewińska, Laura Brewińska, Paulina Drobot, Marcin Wrzosek, Marcin Wrzosek, Marcin Wrzosek   +5 more
doaj   +1 more source

The IFNγ‐CIITA‐MHC II axis modulates melanoma cell susceptibility to NK‐cell‐mediated cytotoxicity

Molecular Oncology, EarlyView.
Natural killer (NK) cells play a central role in anti‐melanoma immunity. However, melanoma cells adapt during co‐culture by upregulating CIITA and MHC II in response to interferon gamma (IFNγ), thereby evading NK‐cell lysis. Blocking IFNγ signaling or treatment with dimethyl fumarate/simvastatin counteracts this immune escape and maintains NK‐cell ...
Lena C. M. Krause, Rixa‐Mareike Köhn, Christian Ickes, Julia Lenger, Jonas Fischer, Sabrina Cappello, Ivan Bogeski   +6 more
wiley   +1 more source

Molecular Microbiological Characteristics of Gingival Pockets in the Periodontal Diseases of Dogs. [PDF]

J Vet Res, 2023
Polkowska I, Tymczyna-Borowicz B, Gołyńska M, Nowicka B.   +3 more
europepmc   +1 more source

Mission to Indonesia to participate to the 1st Indonesia- France Seminar in Medicine & Public Health and investigate potential collaborations on animal health : 2nd - 9th of November 2012 [PDF]

, 2012
Emerging and zoonotic infectious diseases are a major issue in Indonesia. The objective of this mission, funded by the Institut Français d'Indonésie (IFI), was to identify potential subjects of collaboration between CIRAD, Pasteur Institute, and ...
Bourhy, Hervé, Gaidet, Nicolas, Molia, Sophie   +2 more
core