Results 111 to 120 of about 496,181 (282)

Exosome Proteomics of SOD1D90A Mutation Suggest Early Disease Mechanisms, and FN1 as a Biomarker

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Amyotrophic lateral sclerosis (ALS) is a neuromuscular disease. Super oxide dismutase 1 (SOD1) gene mutations cause ALS, and the D90A mutation is associated with primarily upper motor neuron (UMN) loss. Objective Our goal is to reveal the early cellular events in ALS pathology and identify potential pharmacokinetic biomarkers, using well ...
Mukesh Gautam, Ali Laith, Aslihan Gunel, Melda Yilmaz, Nazli Basak, Halil Idrisoglu, P. Hande Ozdinler   +6 more
wiley   +1 more source

Novel Molecular Targets in Malignant Diseases of Digestive System [PDF]

, 2013
Chunping Jiang, Youmin Wu, Qiang Xia, Qin Huang   +3 more
openalex   +1 more source

A Simple Microbiome in the European Common Cuttlefish, Sepia officinalis. [PDF]

, 2019
The European common cuttlefish, Sepia officinalis, is used extensively in biological and biomedical research, yet its microbiome remains poorly characterized.
Abbo, Lisa, Durand, Amber, Gilbert, Jack A, Gottel, Neil R, Hanlon, Roger T, Lutz, Holly L, Mark Welch, Jessica L, Ramírez-Puebla, S Tabita, Schlundt, Cathleen, Sjaarda, Alexandra K   +9 more
core   +1 more source

Growth Differentiation Factor 15 Elevation in the Central Nervous System Is Associated With Failure to Thrive in Alexander Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Alexander disease (AxD) is a severe neurodegenerative disorder caused by gain‐of‐function mutations in the gene for GFAP, which lead to protein aggregation and a primary astrocytopathy. Symptoms vary, but failure to thrive (FTT) and frequent emesis are common and cause significant morbidity. Here we investigate GDF15, a member of the
Tracy L. Hagemann, Michelle M. Sonsalla, Cora Luzinski, Fernando Zacahua, David A. Harris, Dudley W. Lamming, Albee Messing   +6 more
wiley   +1 more source

Digestive System and Severe Acute Respiratory Syndrome Coronavirus 2: New Era of Microbiome Study and Gastrointestinal Tract Manifestations during the Coronavirus Disease-19 Pandemic

, 2021
Alibek Kossumov, Karakoz Mussabay, Astghik Pepoyan, Vardan Tsaturyan, Ketevan Sidamonidze, David Tsereteli, Adil Supiyev, Samat Kozhakhmetov, Laura Chulenbayeva, Marat Dusmagambetov, Massimo Pignatelli, Zhaxybay Zhumadilov, Francesco Marotta, Аlmagul Kushugulova   +13 more
openalex   +2 more sources

CSF Levels of NPTX2 Are Associated With Less Brain Atrophy Over Time in Cognitively Unimpaired Individuals

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Neuronal pentraxin 2 (NPTX2) is a synaptic protein involved in synaptic plasticity and regulation of neuronal excitability. Lower baseline cerebrospinal fluid (CSF) NPTX2 levels have been shown to be associated with an earlier onset of mild cognitive impairment (MCI), a pre‐dementia syndrome, even after CSF Alzheimer's Disease (AD)
Juan P. Vazquez, Corinne Pettigrew, Yuxin Zhu, Claire Anderson, Guray Erus, Christos Davatzikos, Michael Miller, Abhay Moghekar, Sungtaek Oh, Chan‐Hyun Na, Marilyn Albert, Paul Worley, Anja Soldan   +12 more
wiley   +1 more source

Impact of APOE ε4 Genotype Load on Cognitive Function and Lipid Metabolism in Patients With Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Apolipoprotein ε4 (APOE ε4) is a potent genetic risk factor for Alzheimer's disease (AD). However, its role in cerebral small vessel disease (CSVD) remains unclear. Given the clinical and pathological similarities between CSVD and AD, this study aimed to investigate the associations of APOE ε4 gene dosage with cognitive function and
Tingru Jin, Haocheng Yang, Feng Liu, Sihao Lin, Junru Hu, Jian Wang, Yulan Gou   +6 more
wiley   +1 more source

Systematic approach to the development of methods of prevention of gastro-intestinal diseases in newborn calves

Аграрная наука Евро-Северо-Востока, 2017
The main condition for the prevention of diseases in calves in early postnatal period is the formation of an optimal immunological status of cows-mothers, provision of colostral immunity and colonization resistance of mucous membranes in newborn calves ...
O. A. Burova, A. A. Blokhin
doaj  

Immune crosstalk via shared lymph nodes in the upper digestive system influences pancreatic adaptive immunity and alters disease progression 2302 [PDF]

Yixuan Dean Zhou, Hailey Brown, Macy Komnick, Peter Wang, Daria Esterhazy   +4 more
openalex   +2 more sources

Research Progress of Qiweibaizhu Powder in Treating Digestive System Diseases

, 2021
Shiqi Liu, Ji Li
openalex   +1 more source