Results 261 to 270 of about 268,573 (327)

Alnustone Ameliorates Metabolic Dysfunction‐Associated Steatotic Liver Disease by Facilitating Mitochondrial Fatty Acid β‐Oxidation via Targeting Calmodulin

Advanced Science, EarlyView.
This study identifies alnustone, a natural compound from Alpinia katsumadai, as a potent therapeutic agent for MASLD and MASH. Alnustone enhances mitochondrial fatty acid β‐oxidation by directly targeting calmodulin, improving liver steatosis, fibrosis, and insulin resistance in vivo.
Shourui Hu, Xiaofan Liang, Yiming Qin, Yuxuan Li, Yue Liu, Congcong Liu, Zongxuan Lin, Chunxuan Geng, Yanqi Xu, Daimin Wei, Yingying Qin, Han Zhao, Yuqing Zhang, Zi‐Jiang Chen   +13 more
wiley   +1 more source

Study on the improvement of image interpretation skill of non-radiology residents based on an image case database in gastroenterology department. [PDF]

BMC Med Educ
He X, Li Y, Gao C, Zhu X, Xia Q, Han Z, Zhu J.   +6 more
europepmc   +1 more source

Cryptic Splicing of GAP43 mRNA is a Novel Hallmark of TDP‐43‐Associated ALS and AD

Advanced Science, EarlyView.
TDP‐43 dysfunction disrupts RNA processing, inducing cryptic exon 4a1 inclusion in GAP43 and reducing its protein levels. This aberrant splicing impairs axonal regeneration and contributes to neurodegeneration in ALS and AD. RNA‐seq of patient brains reveals GAP43 downregulation and 4a1 upregulation, identifying cryptic exon 4a1 as a potential ...
Mingming Yang, Qi Wang, Dongkun Kang, Shijia Wang, Yanli Jiang, Jian‐Zhi Wang, Chen Ming, Rong Liu, Jianlan Gu, Xiaochuan Wang   +9 more
wiley   +1 more source

Burden of digestive system malignancies and its impact on life expectancy in China, 2004-2021. [PDF]

eGastroenterology
Hu T, Wang S, Wang Y, Wang X, Shang L, Wang K.   +5 more
europepmc   +1 more source

Hospitalization risks associated with floods in a multi-country study. [PDF]

Nat Water
Yang Z, Huang W, McKenzie JE, Xu R, Yu P, Wu Y, Liu Y, Wen B, Zhang Y, Yu W, Ye T, Zhang Y, Ju K, Hales S, Coelho MSZS, Matus P, Tantrakarnapa K, Guo YL, Kliengchuay W, Lavigne E, Phung D, Saldiva PHN, Guo Y, Li S.   +23 more
europepmc   +1 more source

Differential Causal Associations of Chronic Gastritis and Ulcerative Colitis with Melanoma Risk: A Mendelian Randomization Study Using Large-Sample GWAS Data. [PDF]

Clin Cosmet Investig Dermatol
Jin R, Lu J, Cheng S, Shi S.
europepmc   +1 more source

Comorbidity Prevalence in Prediabetes and Type 2 Diabetes: A Cross-Sectional Study in a Predominantly Hispanic U.S.-Mexico Border Population. [PDF]

Int J Environ Res Public Health
Noriega RX, Nañez JJ, Hartmann EF, Beard JD, Sloan-Aagard CD, Thacker EL.   +5 more
europepmc   +1 more source

Medicinal Plant-Derived Exosome-Like Nanovesicles as Regulatory Mediators in Microenvironment for Disease Treatment. [PDF]

Int J Nanomedicine
Feng Z, Huang J, Fu J, Li L, Yu R, Li L.
europepmc   +1 more source

The oncolytic effect of Newcastle disease virus attenuated AMHA1 strain against digestive system tumors

Mohammed A. Hamad, Aous Kahtan Almzaien, Firas R. Jameel, Maeda H. Mohammad, Ahmed Majeed Al-Shammari   +4 more
openalex   +1 more source

Opioid analgesics for sedation-based gastrointestinal endoscopy. [PDF]

World J Gastrointest Pharmacol Ther
Yang WL, Zhou XY, Jiang WC, Zhang XJ, Zhou D.   +4 more
europepmc   +1 more source