Results 291 to 300 of about 3,158,446 (357)
Macrophage HM13/SPP Enhances Foamy Macrophage Formation and Atherogenesis
Previous research suggests that AIP may prevent atherogenic foamy macrophage formation. This study reveals that AIP, via its chaperone interaction with AHR, inhibits p38‐c‐JUN‐mediated transactivation of HM13, which encodes the ERAD protease HM13/SPP. HM13/SPP promotes foamy macrophage formation in addition to atherogenesis and plaque foamy macrophage ...
Yu Cao+15 more
wiley +1 more source
Snare-assisted submucosal tunneling for resection of esophageal schwannomas: Case Report. [PDF]
Cao X, Li J.
europepmc +1 more source
This study investigates the metabolic vulnerabilities of glioblastoma (GBM), an aggressive brain tumor. Research demonstrates that iron chelation therapy, in combination with standard chemotherapy, significantly enhances the efficacy of treatment against resistant GBM cells in a 3D tumoroid model.
Meitham Amereh+8 more
wiley +1 more source
Unlocking the power of probiotics, postbiotics: targeting apoptosis for the treatment and prevention of digestive diseases. [PDF]
Xie Q+5 more
europepmc +1 more source
PRKCQ‐AS1 is overexpressed due to transcriptional super‐enhancers. PRKCQ‐AS1 RNA forms a complex with MSI2 protein to induce BMX mRNA stabilization and overexpression, ERK protein phosphorylation and neuroblastoma cell proliferation. Compound NSC617570 blocks PRKCQ‐AS1 binding to MSI2, leading to BMX mRNA disassociation from MSI2 protein, BMX reduction,
Sujanna Mondal+23 more
wiley +1 more source
Artesunate: A Review of Its Potential Therapeutic Effects and Mechanisms in Digestive Diseases. [PDF]
Shi M, Ma G, Yang X.
europepmc +1 more source
As a downstream target of α2δ1‐mediated calcium signaling, SIRT4 serves as an oncogene to promote the stemness of pancreatic cancer via deacetylating ENO1 directly at K358, leading to attenuated ENO1's RNA‐binding capacity, enhanced glycolytic substrate 2‐PG binding and robust glycolytic activity to increase the level of lactate that induce histone ...
Mengzhu Lv+10 more
wiley +1 more source
Impact of microplastics on the human digestive system: From basic to clinical. [PDF]
Wang YF+5 more
europepmc +1 more source
Omicsformer, a deep learning model, integrates multi‐omics and routine blood data to accurately predict risks for nine chronic diseases, including cancer and cardiovascular conditions. Validated using large scale clinical data, it reveals early risk trajectories, advancing personalized medicine and offering a cost‐effective, community‐based solution ...
Zhibin Dong+20 more
wiley +1 more source
MicroRNAs in the Diagnosis of Digestive Diseases: A Comprehensive Review. [PDF]
Popa ML+4 more
europepmc +1 more source