Results 151 to 160 of about 93,090 (280)

Primary Hyperparathyroidism in Adults: Recent Developments in Diagnosis and Management. [PDF]

Med J Aust
Wootton E, De Sousa SMC, Prince RL, McLeod DSA, Pattison DA, Grossmann M.   +5 more
europepmc   +1 more source

Endocrine side effects of immune checkpoint inhibitors in treatment of malignant diseases

Maligne bolesti predstavljaju jedan od vodećih javnozdravstvenih problema globalno, ali i u Hrvatskoj, gdje su drugi uzrok smrtnosti nakon kardiovaskularnih bolesti.
Hadelan, Lucija
core  

ZDHHC17‐Mediated CDK4 Palmitoylation Drives Cell Cycle Progression and Orchestrates Cancer Immune Surveillance

Advanced Science, EarlyView.
ZDHHC17 palmitoylates CDK4, which together with TRAF6‐mediated ubiquitination, drives cell cycle progression and immune surveillance, revealing a rational combination of CDK4 inhibitors with immune checkpoint blockers for ZDHHC17‐driven cancers. ABSTRACT Uncontrolled cell cycle progression is a hallmark of cancer, tightly regulated by both intrinsic ...
Zekang Wang, Peipei Song, Xueji Wu, Lei Wang, Wei Xie, Pinning Feng, Chao Cheng, Jianping Guo   +7 more
wiley   +1 more source

Increased Frequency and Distinct Genotypic Patterns of Somatic Aldosterone-Driver Mutations in Aldosterone-Producing Micronodules from Primary Aldosteronism Patients. [PDF]

Endocr Pathol
Lim JS, Wu CY, Qin Z, Liu CJ, van Rooyen D, Sapiro DR, Giordano TJ, Turcu AF, Rainey WE, Udager AM.   +9 more
europepmc   +1 more source

ABHD17C‐Mediated S‐Depalmitoylation of BCL6B Enhances CD24 Transcription to Resist Macrophage Phagocytosis in Pancreatic Cancer

Advanced Science, EarlyView.
ABHD17C‐mediated depalmitoylation of BCL6B at Cys442 blocks its nuclear import and triggers ubiquitin‐dependent degradation, attenuating transcriptional repression of the anti‐phagocytic signal CD24. This mechanism enables pancreatic cancer cells to evade macrophage phagocytosis and fosters an immunosuppressive microenvironment.
Yalu Zhang, Di Cui, Fanzheng Meng, Xu Zhu, Liang Zhu, Liang Wu, Haifeng Hu, Jizhou Wang, Hanhui Yao, Lianxin Liu   +9 more
wiley   +1 more source

Breast cancer-related endocrine therapy on ocular surface microbiota: mechanism and clinical significance. [PDF]

Int J Ophthalmol
Yuan C, Hu XC, Tan RX, Liu C.
europepmc   +1 more source

Reprogramming the Immune Landscape of Inflammatory Breast Cancer

Advanced Science, EarlyView.
Inflammatory breast cancer is the most lethal subtype of breast cancer and is characterized by an immunosuppressive tumor microenvironment (TME) driven by a complex network of immune cells and inflammatory cytokines, contributing to its aggressiveness and treatment challenges. Immune checkpoint inhibitors, either alone or in combination, show potential
Verena Martinez‐Rodriguez, Suguru Ogata, Xiaoping Wang, Naoto T. Ueno   +3 more
wiley   +1 more source

Vascularity Assessment of Parathyroid Glands Using Low-Dose ICG and Probe-Based Fluorescence Detection. [PDF]

Ann Surg Oncol
Willmon PA, Thomas G, Kiernan CM, Baregamian N, Solórzano CC, Mahadevan-Jansen A.   +5 more
europepmc   +1 more source

Endocrine disorders and diabetes mellitus in patients on hemodialysis

The kidney plays an essential role in producing and metabolizing many hormones. Therefore, uremia is accompanied by significant endocrine changes. End-stage renal disease (ESRD) is a significant health problem due to the increased risk of morbidity and ...
Çiftel, Serpil, Mercantepe, Filiz
core  

Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects

Advanced Science, EarlyView.
Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu, Ke Wang, Kaizhong Lu, Tianlun Hou, Yuan Chen, Xian Wang, Hongchuan Jin   +6 more
wiley   +1 more source