Results 131 to 140 of about 181,905,299 (309)

Characterizing white matter hyperintensities in myotonic dystrophy type 1 through IVIM derived metrics

Scientific Reports
Myotonic dystrophy type 1 (DM1) is a genetic disease which affects multiple systems including the central nervous system. One of its key neuroimaging biomarkers are white matter hyperintensities (WMHs). The clinical relevance of WMHs remains unclear, and
Marina Di Stefano, Nivedita Agarwal, Giulia Canella, Eleonora Diella, Morena delle Fave, Giovanni Meola, Maria Grazia D’Angelo, Denis Peruzzo   +7 more
doaj   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Imaging of parasitic diseases of the central nervous system

, 2008
Infections of the central nervous system (CNS), especially parasitic infections, have increased in the last decade secondary to the acquired immunodeficiency syndrome (AIDS) epidemic, immunosuppressive therapy used in treatment of cancer, and in organ ...
Hourani R.G., Tamraz J.C.
core   +1 more source

Association of clear vs blue-light filtering intraocular lenses with mental and behavioral disorders and diseases of the nervous system among patients receiving bilateral cataract surgery. [PDF]

J Cataract Refract Surg, 2023
Karesvuo M, Kanclerz P, Hecht I, Achiron A, Tuuminen R.   +4 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Digital-Intellectualized Upgrade and Clinical Application of National Rare Diseases Registry System of China

Since its establishment in 2016, the National Rare Diseases Registry System of China (NRDRS) has accumulated valuable case data and bio-specimen for basic and clinical research on rare diseases in China.
GUO Jian, JIN Ye, LIU Peng, CHEN Limeng, ZHANG Shuyang, on behalf of the administrative group of National Rare Diseases Registry System of China, ZHANG Dingding, ZHU Yicheng   +7 more
core   +1 more source

Drugs and the somatic nervous system [PDF]

, 2012
Drugs and the somatic nervous system\ud 8.1 The somatic nervous system\ud 8.2 Anticholinesterases\ud 8.3 Neuromuscular blockers\ud 8.4 ...
Doggrell, Sheila
core  

Pregnancy and Autoimmune Disease. [PDF]

Dtsch Arztebl Int, 2022
Merz WM, Fischer-Betz R, Hellwig K, Lamprecht G, Gembruch U.   +4 more
europepmc   +1 more source

Understanding Further the Phenotypic Spectrum of Central Nervous System Inflammatory Demyelinating Disorders Using Unsupervised Clustering

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Central nervous system (CNS) inflammatory demyelinating syndromes, including multiple sclerosis (MS), aquaporin‐4 antibody–positive neuromyelitis optica spectrum disorder (AQP4 + NMOSD), and myelin oligodendrocyte glycoprotein (MOG) antibody–associated disease (MOGAD), occasionally overlap.
Bade Gulec, Elif Everest, Melih Tutuncu, Ugur Bilge, Sabahattin Saip, Ugur Uygunoglu, Aksel Siva   +6 more
wiley   +1 more source

Targeting DNM1L/DRP1-FIS1 axis inhibits high-grade glioma progression by impeding mitochondrial respiratory cristae remodeling

Journal of Experimental & Clinical Cancer Research
Background The dynamics of mitochondrial respiratory cristae (MRC) and its impact on oxidative phosphorylation (OXPHOS) play a crucial role in driving the progression of high-grade glioma (HGG). However, the underlying mechanism remains unclear.
Xiaodong Li, Jingjing Tie, Yuze Sun, Chengrong Gong, Shizhou Deng, Xiyu Chen, Shujiao Li, Yaoliang Wang, Zhenhua Wang, Feifei Wu, Hui Liu, Yousheng Wu, Guopeng Zhang, Qingdong Guo, Yanling Yang, Yayun Wang   +15 more
doaj   +1 more source