Results 271 to 280 of about 1,195,331 (367)

Spatiotemporal Patterns of Non-Communicable Disease Mortality in the Metropolitan Area of the Valley of Mexico, 2000-2019. [PDF]

Diseases
González-Salazar C, Gasca-Gómez K, Cordero-Saldierna O.   +2 more
europepmc   +1 more source

Loss of NR2F6 Protects from Salmonella Typhimurium Infection

Advanced Science, EarlyView.
Loss of nuclear receptor NR2F6 reduces tissue‐resident macrophage populations. Nr2f6‐deficient mice are protected from weight loss and bacterial load during infection with Salmonella Typhimurium. Pro‐inflammatory cytokines and iron levels are altered in infected Nr2f6‐deficient mice.
Johannes Woelk, Christa Pfeifhofer‐Obermair, Julia Benz, Natascha Brigo, Milena Bamberger, Alexeja Kleiter, Martin Hermann, Guenter Weiss, Natascha Hermann‐Kleiter   +8 more
wiley   +1 more source

METTL14‐Mediated M6A Modification of LINC01094 Induces Glucose Metabolic Reprogramming in Breast Cancer by Recruiting the PKM2/JMJD5 Complex

Advanced Science, EarlyView.
METTL14/IGF2BP2‐mediated m6A modification drives LINC01094 upregulation in BC. Then, LINC01094 interacts with PKM2 monomers to promote their dimerization, while serving as a flexible scaffold to facilitate the assembly of the PKM2/JMJD5 complex, synergistically stabilizing PKM2 dimers and enhancing their nuclear translocation.
Mengqi Wang, Zhaoxin Gao, Ruinan Zhao, Pan Zhou, Jingxi Chen, Hui Zhang, Yawen Wang, Wenjie Zhu, Peng Gao   +8 more
wiley   +1 more source

Additive effect of wildfires on hospital admission in the Pantanal wetland, Brazil. [PDF]

Sci Rep
Gonçalves AC, de Magalhães MM, de Almeida Lopes Fernandes GA, Fernandes IF, de Almeida Faria K, Dos Santos GA, Valentim R, do Nascimento GM, Rodrigues FA, Ceneviva R, Stama MCM, Mori DTG, Capellini CN, Garcia MEF, Bruschi T, Gonçalves GP, Brito LC, Toussaint DDE, Gonçalves RC, Luiz OC.   +19 more
europepmc   +1 more source

Acod1 Promotes PAD4 Ubiquitination via UBR5 Alkylation to Modulate NETosis and Exert Protective Effects in Sepsis

Advanced Science, EarlyView.
In this study, Acod1 knockout in CLP mice significantly increases peripheral blood NET levels, exacerbating inflammation, organ damage, and reducing survival. Further research shows that UBR5 interacts with PAD4, a key NET formation protein. Acod1/itaconate (ITA) enhances the enzymatic activity of UBR5 by alkylating the Cys2768 site, promoting the K48 ...
Huifan Liu, Guoqing Jing, Shujuan Wu, Min Yuan, Yingyue Dong, Xue Chen, Huimin Zhou, Hailong Gong, Jing Zuo, Xiaojing Wu, Xuemin Song   +10 more
wiley   +1 more source

Xenobiotic Toxicants and Particulate Matter: Effects, Mechanisms, Impacts on Human Health, and Mitigation Strategies. [PDF]

J Xenobiot
Lang T, Lipp AM, Wechselberger C.
europepmc   +1 more source

Possibilities for predicting the course of fibrosing interstitial lung diseases based on a comprehensive study of the cardio-respiratory system

А. А. Obukhova, А. Н. Куликов, Yu. D. Rabik, M. I. Butomo, A. V. Zinchenko, N. V. Markov, З. А. Зарипова, Dali Dzadzua, Elena V. Obukhova, А. Х. Ахминеева, Lubov Novikova   +10 more
openalex   +2 more sources

Brain‐Wide Spatiotemporally Distinct Traveling Waves Drive Anxiety‐Like Behaviors in Mice

Advanced Science, EarlyView.
J.Liu et al. reveal the complete propagation dynamics of cortical traveling waves, from local circuitry initiation to long‐range propagation, and identify their functional relevance in modulating anxiety‐like behaviors and underlying cellular neuroplasticity in mice.
Jiaming Liu, Jia‐Wen Mo, Xunda Wang, Yinuo Ma, Shile Tian, Qi Wang, Peng‐Li Kong, Ziqi An, Li Ding, Jing Ren, Cheng‐Lin Lu, Chuanjun Tong, Ed X. Wu, Qiu‐gen Hu, Xiong Cao, Yanqiu Feng   +15 more
wiley   +1 more source

Enhancing regional disease burden estimates: insights from the comparison of Global Burden of Disease and China's notifiable infectious diseases data with policy implications (2010-2020). [PDF]

Infect Dis Poverty
Zhao ZY, Li JJ, Ouyang HQ, Li WH, Huang SK, Ohore OE, Wang L, Utzinger J, Yang GJ.   +8 more
europepmc   +1 more source