Results 51 to 60 of about 203,368 (270)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
PLoS ONE, 2021 BackgroundObsessive-compulsive disorder (OCD) has long been considered as an anxiety disorder, disgust is the dominant emotion in contamination-based OCD.
Caroline Novara +6 more
doaj +1 more source
Beyond Purity: Moral Disgust toward Bad Character [PDF]
, 2016 Previous studies support a link between moral disgust and impurity, while anger is linked to harm. We challenge this strict correspondence, and show that disgust is sensitive to information about moral character, even for harm violations.
Beaupré M. G. +7 more
core +1 more source
FEBS Open Bio, EarlyView.We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source
Real‐World Investigation of Satralizumab in Patients With Neuromyelitis Optica Spectrum Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Satralizumab, a monoclonal antibody targeting the interleukin‐6 receptor, has demonstrated efficacy in clinical trials for neuromyelitis optica spectrum disorder (NMOSD). However, its real‐world effectiveness and safety compared to conventional immunosuppressive therapies remain uncertain.
Li‐Tsung Lin +2 more
wiley +1 more source
Explaining public support for counterproductive homeless policy: the role of disgust [PDF]
, 2017 Federal, state, and city governments spend substantial funds on programs intended to aid homeless people, and such programs attract widespread public support.
Piston, S.
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang +10 more
wiley +1 more source
Transgressions and expressions: Affective facial muscle activity predicts moral judgments [PDF]
, 2011 Recent investigations into morality suggest that affective responses may precede moral judgments. The present study investigated, first, whether individuals show specific facial affect in response to moral behaviors and, second, whether the intensity of
Cannon, PR, Schnall, S, White, M
core
Vestibular Patient Journey: Insights From Vestibular Disorders Association (VeDA) Registry
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Vestibular symptoms impose a high burden of disability. Understanding real‐world diagnostic and treatment pathways can identify care gaps and guide interventions. We aimed to characterize symptom profiles, diagnostic trends, provider involvement, and treatment patterns in vestibular disorders.
Ali Rafati +10 more
wiley +1 more source
, 2019 Research on disgust connects to a surprisingly large variety of topics across the behavioral sciences and humanities. It serves as a case study in debates about the nature of emotions themselves, their relationship to cognition and affect, whether and how much they might be innately constrained or socially constructed, which parts might be universal ...
Daniel Linford +2 more
+5 more sources