USP35 Acts as a Deubiquitinating Enzyme for ID3 to Promote Immune Escape in Colorectal Cancer
Advanced Science, EarlyView.USP35 stabilizes ID3 expression by deubiquitinating the K2/K30 site, thereby upregulating PD‐L1 and promoting immune escape in colorectal cancer. IU1, an inhibitor of USP35 enzyme activity, has been shown to inhibit USP35, thereby accelerating ID3 degradation, enhancing CD8+ T cell killing, and reversing the immunosuppressive microenvironment ...
Wenxin Chen +9 more
wiley +1 more source
Clean sweep or pathogen paradise? A critical review of cleaning and disinfection practices in broiler barns. [PDF]
Poult SciDrögmöller A, Louton H.
europepmc +1 more source
Operating room disinfection: operator-driven ultraviolet ‘C’ vs. chemical treatment
, 2023 Marie-Claire Fickenscher +6 more
openalex +1 more source
Advanced Science, EarlyView.IL27RA upregulation drives immune evasion in TNBC by suppressing MHC‐I expression and reprogramming T/NK‐cell states, establishing an immune‐excluded tumor phenotype. Targeting this epithelial‐intrinsic IL27RA–PI3K/AKT axis offers a promising strategy to overcome immunotherapy resistance.
Jiachi Xu +8 more
wiley +1 more source
Simultaneous removal of estrogens and pathogens from secondary treated wastewater by solar photocatalytic treatment [PDF]
, 2014 Chatzisymeon, E. +4 more
core
Advanced Science, EarlyView.This study demonstrates meningeal lymphatic impairment associated with lung adenocarcinoma brain metastasis progression in both human patients and mouse models, establishes clinically applicable non‐invasive imaging biomarkers for quantitative analyzing mLV structure and function, and reveals mLVs as robust prognostic indicators and promising potential
Yuan Zhang +15 more
wiley +1 more source
Subcutaneous tissue disinfection is more effective than the use of electrocautery in reducing <i>Cutibacterium acnes</i> burden in open shoulder surgery. [PDF]
JSES IntGallusser N +4 more
europepmc +1 more source
Universal Solvent Escape Strategies for Efficient Curing of Hydrogen‐Bond‐Rich 3D Printing Inks
Advanced Science, EarlyView.This study developed a new 3D printing method for hydrogen‐bonded polymers by combining solvent replacement, nanoparticles, and optimized printing paths. This allows fast, precise scaffold fabrication. The scaffolds can be easily customized and release therapeutic agents slowly through protonation, enabling personalized bone, blood vessel, and nerve ...
Jie Chen +11 more
wiley +1 more source
Preliminary investigation of bacterial surface contamination in emergency ambulances in South Korea. [PDF]
Int J Emerg MedNam SH, Lee HJ, Choi MY.
europepmc +1 more source