Results 111 to 120 of about 103,062 (307)

Occurrence of disinfection by-products in the Krakow water supply system with respect to compliance EU standards

Desalination and Water Treatment
The research explored the presence of disinfection by-products (DBPs) in drinking water supplied to the Krakow agglomeration and compared it with the guidelines in Directive (EU) 2020/2184. The paper looked particularly into DBPs: haloacetic acids (HAA),
Monika Ochmańska, Małgorzata Cimochowicz-Rybicka, Dominika Łomińska-Płatek, Tadeusz Bochnia   +3 more
doaj   +1 more source

A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model

Advanced Science, EarlyView.
This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang, Yongpeng Qin, Bin Luo, Fan Bai, Jiangyue Liu, Long Ma, Shu He, Rongjie Chen, Yuchen Wang, Shanggong Liu, Ying Sun, Yi Chen, Shuo Zhang, Jiaqi Liang, Feng Liao, Huiyi Wei, Junjie Wei, Lu Wang, Hao Xu, Zheng Wu, Gong Chen, Wenliang Lei   +21 more
wiley   +1 more source

Immobilized photosensitizers for antimicrobial applications [PDF]

, 2015
Photodynamic antimicrobial chemotherapy (PACT) is a very promising alternative to conventional antibiotics for the efficient inactivation of pathogenic microorganisms; this is due to the fact that it is virtually impossible for resistant strains to ...
Boyle, Ross W., Spagnul, Cinzia, Turner, Lauren C.   +2 more
core   +1 more source

An Implantable Scaffold Sequentially Releasing STING Agonist and B7‐H3 Antibody for Bone Metastasis Immunotherapy

Advanced Science, EarlyView.
We developed an implantable dual‐drug depot using GelMA for bone metastasis treatment, co‐delivering MSA‐2 and αB7‐H3‐loaded CaCO3 microparticles. Sustained release from GelMA scaffold enables MSA‐2 to activate STING signaling and enhance T‐cell infiltration and activation, while sequentially released αB7‐H3 blocks MSA‐2‐induced B7‐H3 upregulation ...
Qijun Lin, Hong Xiao, Shuai Fan, Kaimin Cai, Yanteng Xu, Xinwen Wang, Guanhong Chen, Chuandong Lang, Xinsheng Peng, Mingqiang Li, Yuhu Dai   +10 more
wiley   +1 more source

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

Advanced Science, EarlyView.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu, Yaqian Cui, Yongqiang Zhou, Yihui Zheng, Lijiang Huang, Leiming Jin, Qianhui Zhang, Pan Chen, Mengsha Lin, Jiaxi Ye, Yongqiang Xiong, Joo Young Huh, Xiang Hu, Xiaokun Li, Wu Luo, Guang Liang   +15 more
wiley   +1 more source

Disinfection methods and by-products formation

Desalination and Water Treatment, 2015
AbstractWater disinfection is a necessary process for the control of the pathogenic micro-organisms. However, the use of chemical disinfectants leads to the formation of disinfection by-products (DBPs). While the pathogenic micro-organisms are the primary cause of human health risk from water, DBPs also provide an unintended health hazard. Chlorination,
I. Voukkali, A.A. Zorpas
openaire   +1 more source

Minimization of algogenic organic matter from cyanobacteria-laden water by electrochemical oxidation: molecular degradation signature of disinfection by-products precursors by electro-oxidation and electro-Fenton

Sustainable Environment Research
Algogenic organic matter (AOM) generated from cyanobacteria-impacted reservoirs poses a significant risk to drinking water. This study aimed to investigate the molecular degradation signature of Microcystis aeruginosa (MA)-derived AOM by electrochemical ...
Angga Aji, Fahrudin Sidik, Jr-Lin Lin
doaj   +1 more source

Perborate Activated Peroxymonosulfate Process for Improving the Coagulation Efficiency of Microcystis aeruginosa by Polymeric Aluminum Chloride

Molecules
In this study, the sodium perborate (SP)-activated peroxymonosulfate (PMS) process was used to enhance the coagulation efficiency of cyanobacteria with polymeric aluminum chloride (PAC), aiming to efficiently mitigate the impact of algal blooms on the ...
Fan Chen, Lu Li, Shunfan Qiu, Shiyang Chen, Lingfang Yang, Lin Deng, Zhou Shi   +6 more
doaj   +1 more source

Artesunate Ameliorates APAP‐induced Liver Injury by Promoting NEDD4L‐Mediated Ubiquitination and Degradation of TXNIP

Advanced Science, EarlyView.
ABSTRACT Liver injury can lead to severe acute liver failure and even death in patients. Artesunate (ART), which is a derivative of artemisinin that has been approved by the FDA for the treatment of malaria, has significant regulatory effects on cell death and inflammation.
Zhe Zhang, Hongyi Zhang, Haixiang Guo, Xiwen Zhang, Yidan Wang, Baoyin Wang, Tong Wang, Guokun Zhao, Qing Zhang, Fei Gao, Shuang Liang, Hao Jiang, Yu Ding, Xiliang Du, Jiabao Zhang, Yi Zheng, Xinwei Li, Bao Yuan   +17 more
wiley   +1 more source

Challenges and opportunities for mitigating the risk of trihalomethane exposure in public water supplies in Queensland

Discover Water
Trihalomethanes (THMs), water disinfection byproducts resulting from the reaction of chlorine with organic matter during drinking water disinfection, pose potential long-term health risks.
Edmund Wedam Kanmiki, Yaqoot Fatima, Fran Boyle, Phil Min Choi, Md. Mehedi Hasan, Abdullah A. Mamun   +5 more
doaj   +1 more source