Results 11 to 20 of about 4,401 (143)

Liver proteome of mice with different genetic susceptibilities to the effects of fluoride

Journal of Applied Oral Science, 2016
A/J and 129P3/J mice strains have been widely studied over the last few years because they respond quite differently to fluoride (F) exposure. 129P3/J mice are remarkably resistant to the development of dental fluorosis, despite excreting less F in urine
Zohaib Nisar KHAN, Aline de Lima LEITE, Senda CHARONE, Isabela Tomazini SABINO, Tatiana MARTINI, Heloísa Aparecida Barbosa da Silva PEREIRA, Rodrigo Cardoso OLIVEIRA, Marília Afonso Rabelo BUZALAF   +7 more
doaj   +3 more sources

Identifizierung von Protein-Protein-Interaktionen in vitro auf Grundlage von Hochdichte-Protein-Arrays

, 2004
In dieser Arbeit wurde eine in vitro-Strategie zur Identifizierung und Verifizierung von Protein-Protein-Interaktionen auf Grundlage von Hochdichte-Protein-Arrays entwickelt.
Faupel, Thomas
core   +1 more source

Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes

, 2014
The human proteome contains a plethora of short linear motifs (SLiMs) that serve as binding interfaces for modular protein domains. Such interactions are crucial for signaling and other cellular processes, but are difficult to detect because of their low
Ivarsson, Ylva,, Moffat, Jason,, Arnold, Roland,, Li, Shawn Shun-Cheng, Sidhu, Sachdev S, Arnold, Roland, Kim, Philip M,, Ivarsson, Ylva, Ray, Debashish,, Liu, Bernard,, Joshi, Rakesh, Liu, Bernard, Sidhu, Sachdev S,, Li, Shawn Shun-Cheng,, Moffat, Jason, Nim, Satra,, Teyra, Joan, Joshi, Rakesh,, McLaughlin, Megan,, Nim, Satra, Kim, Philip M, Teyra, Joan,, Pawson, Tony, McLaughlin, Megan, Pawson, Tony,, Ray, Debashish   +25 more
core   +1 more source

Time-dependent changes in the mouse hippocampal synaptic membrane proteome after contextual fear conditioning.

, 2015
A change in efficacy of hippocampal synapses is critical for memory formation. So far, the molecular analysis of synapses during learning has focused on small groups of proteins, whereas the dynamic global changes at these synapses have remained unknown.
Rao-Ruiz, P, Pandya, Naushira, Priyanka Rao‐Ruiz, Rolinka J. van der Loo, Loo, R.J., Smit, A.B., Smit, A B, August B. Smit, van der Loo, R J, Carney, K.E., Sabine Spijker, Spijker, S., Karen E. Carney, Spijker, S, Nikhil Pandya, Verheijen, M H, Rao-Ruiz, P., Mark H.G. Verheijen, Verheijen, M.H.G., Carney, K E, Pim van Nierop, Pandya, N.J., van Nierop, P., van Nierop, P   +23 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Hijacking the Host Clock: A Nematode Effector Antagonizes Soybean Circadian Defense and Translation Control

Advanced Science, EarlyView.
Soybean employs its circadian clock, governed by GmCCA1, to rhythmically defend against soybean cyst nematodes. The pathogen retaliates by secreting the effector Hg4E02, which hijacks the clock to suppress defense and co‐opt the host's translation machinery for nutrient acquisition.
Xingwei Wang, Yufeng Xu, Yanfei Hu, Lijun Cao, Ru Jiang, Changtian Chen, Rick Masonbrink, Thomas Maier, Yuchen Tu, Yabo Shi, Enhui Liu, Lingan Kong, Chan Guo, Wei Zhao, Peng Shi, Wenzhen Du, Andrew Severin, Thomas Baum, Deliang Peng, Huan Peng, Mian Zhou, Wei Wang   +21 more
wiley   +1 more source

Combining Fret and Super‐Resolution Microscopy Reveals Kinase Activation and Mitochondrial Activity at the Nanoscale

Advanced Science, EarlyView.
BioSenSRRF is an open‐source workflow that combines conventional FRET biosensors with SRRF reconstruction to generate sub‐diffraction FRET index maps on standard microscopes. The pipeline integrates automated image registration, SRRF reconstruction, quantitative FRET index calculation, and random line‐based hotspot analysis to uncover AURKA‐dependent ...
Nicolas Y. Jolivet, Pierre‐Jean Desmaison, Xavier Pinson, Arthur Masson, Olivier Delalande, Giulia Bertolin   +5 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Spontaneous Non‐Catalyzed Molecular Reactions and Interactions in the Human Body: Biomedical Implications

Advanced Science, EarlyView.
ABSTRACT The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions.
Yuhao Cai, Chao Zhao
wiley   +1 more source

Fine‐Tuned Regulation of mRNA Translation and Transport by STAU2 Condensate Facilitates Neuronal Development and Plasticity

Advanced Science, EarlyView.
STAU2 undergoes phase separation to form dynamic condensates that package target mRNAs and deliver them to the distal ends of growing neuronal dendrites. STAU2 condensates stabilize embedded mRNAs and repress their translation. Synaptic activity bidirectionally remodels STAU2 condensates, coordinating local translation of STAU2‐associated mRNAs ...
Shijing Huang, Yuanyuan Chu, Ruiqian Zhao, Siyu Li, Yu Feng, Hongdan Zheng, Yunli Xie, Tong Wang, Wenyu Wen   +8 more
wiley   +1 more source