Results 121 to 130 of about 21,834 (238)

Rationale and Trial Design of DAWNA‐FES Trial: Single‐Arm Phase II Study of Endocrine Therapy With Dalpiciclib After Progression on CDK4/6 Inhibition Based on [18F]FES PET/CT in Patients With HR+/HER2− Advanced Breast Cancer

Cancer Innovation, Volume 5, Issue 3, June 2026.
The DAWNA‐FES trial is a prospective, single‐center, single‐arm phase II study evaluating dalpiciclib plus endocrine therapy in patients with HR+/HER2− advanced breast cancer who have progressed on prior CDK4/6 inhibitors and have at least one [18F]FES‐positive lesion.
Ru Yao, Yang Qu, Zhixin Hao, Ying Xu, Jiahui Zhang, Jie Lian, Lu Gao, Songjie Shen, Feng Mao, Bo Pan, Qiang Sun, Li Huo, Yidong Zhou   +12 more
wiley   +1 more source

Clinical, Hormonal and Genetics Features in patients with Androgen Insensitivity Syndrome in Cytogenetic Laboratories in Semarang [PDF]

, 2006
Androgen insensitivity syndrome (AIS) is an X-linked disorder caused by impaired Androgen Receptor (AR) which is encoded in Xq 11-12. In this condition, although the androgen is produced sufficiently, but the peripheral masculinizing effect is blocked ...
Tonang, Alvin
core  

Temporal Metabolomics Profiling Reveals Liver Metabolic Control in Single and Repeated Exhaustive Exercise in Murine Models

The FASEB Journal, Volume 40, Issue 9, 15 May 2026.
Temporal metabolomics profiling reveals divergent liver recovery trajectories between single and repeated exhausted exercise stress. Single exhaustive exercise (SEE) demonstrates transient metabolic perturbations resolving within 24 h. In contrast, repeated exhaustive exercise (REE) triggers sustained metabolic remodeling that persists beyond the ...
Jining Yang, Dawei Wang, Hui Shen, Yundong Xia, Hedong Lang, Wenxin Zhou, Long Yi, Mantian Mi   +7 more
wiley   +1 more source

The heartbreak of depression: 'Psycho-cardiac' coupling in myocardial infarction [PDF]

, 2017
Ample evidence identifies strong links between major depressive disorder (MDD) and both risk of ischemic or coronary heart disease (CHD) and resultant morbidity and mortality. The molecular mechanistic bases of these linkages are poorly defined. Systemic
Budiono, Boris P, Headrick, John P., Neumann, David L., Peart, Jason N., Shum, David H K, Stapelberg, Nicolas J C   +5 more
core   +1 more source

GPND‐AI NULISA: A 15‐Protein AI classifier for diagnosis and co‐pathology profiling across neurodegenerative diseases

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Accurate clinical diagnosis of neurodegenerative diseases remains challenging, particularly when individuals have mixed pathologies. We implemented the generalizable protein‐based neurodegenerative disease artificial intelligence (GPND‐AI) classifier using the NUcleic acid‐Linked Immuno‐Sandwich Assay (NULISA) central nervous ...
Ying Xu, Marisa N Denkinger, Menghan Liu, Katherine Gong, Yike Chen, Daniel Western, Jigyasha Timsina, Yuchen Cheng, Yunchang Xie, Rui Mu, John Budde, Thomas G. Beach, Geidy E. Serrano, Eric M. Reiman, Alpana Singh, Isabel Alfradique‐Dunham, Tammie L. S. Benzinger, Suzanne E. Schindler, John C. Morris, David M. Holtzman, Joel S. Perlumtter, B Joy Snider, Meghan C. Campbell, Paul T. Kotzbauer, Nicholas J. Ashton, Carlos Cruchaga   +25 more
wiley   +1 more source

Application of the New Classification on Patients with a Disorder of Sex Development in Indonesia

International Journal of Endocrinology, 2012
Disorder of sex development (DSD) patients in Indonesia most often do not receive a proper diagnostic evaluation and treatment. This study intended to categorize 88 Indonesian patients in accordance with the new consensus DSD algorithm.
A. Zulfa Juniarto, Yvonne G. van der Zwan, Ardy Santosa, Remko Hersmus, Frank H. de Jong, Renske Olmer, Hennie T. Bruggenwirth, Axel P. N. Themmen, Katja P. Wolffenbuttel, Leendert H. J. Looijenga, Sultana M. H. Faradz, Stenvert L. S. Drop   +11 more
doaj   +1 more source

Health status in 1040 adults with disorders of sex development (DSD): a European multicenter study

Endocrine Connections, 2018
Objective: The knowledge about health status in adults with disorder of sex development (DSD) is scarce. Design and methods: A cross-sectional observational study in 14 European tertiary centers recruited 1040 participants (717 females, 311 males, 12 ...
Henrik Falhammar, Hedi Claahsen-van der Grinten, Nicole Reisch, Jolanta Slowikowska-Hilczer, Anna Nordenström, Robert Roehle, Claire Bouvattier, Baudewijntje P C Kreukels, Birgit Köhler   +8 more
doaj   +1 more source

A Rare Cause of a 46,XY Disorders of Sex Development: Persistent Mullerian Duct Syndrome

Journal of Dr Behcet Uz Children s Hospital, 2017
Persistent mullerian duct syndrome (PMDS) is a relatively rare form of a 46, XY disorders of sex development and clinically characterized by undescended testes and the presence of mullerian duct derivatives such as a uterus and fallopian tubes in males with normal external genitalia.
Acar, Sezer, Paketci, Ahu, Onay, Huseyin, Demir, Korcan, Ates, Oguz, Bober, Ece, Abaci, Ayhan   +6 more
openaire   +3 more sources

Circulating Level of Growth‐Differentiation Factor 15 and Mortality of Patients With Acute Heart Failure: A Meta‐Analysis

Clinical Cardiology, Volume 49, Issue 5, May 2026.
Elevated admission GDF‐15 levels are associated with increased mortality in acute heart failure. This meta‐analysis of 10 studies (N = 3724) found a pooled RR of 2.82 (95% CI: 2.39–3.32; p < 0.001; I² = 0%), supporting GDF‐15 as a promising biomarker for early risk stratification in AHF patients.
Pingkui Jin, Yanjie Geng, Erwei Huo, Yanhong Xue, Daofeng You, Qinghou Zheng   +5 more
wiley   +1 more source

Clinical Features of Malignant Ovarian Germ Cell Tumors According to Demographic and Pathologic Characteristics

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aims Malignant ovarian germ cell tumors (MOGCTs) are aggressive cancers affecting mainly young women, in whom fertility preservation is important. Diagnosis is often delayed because early symptoms are non‐specific, leading to advanced disease or emergency surgery that may limit optimal staging and fertility‐sparing treatment. As
Jila Agah, Elham Navipour, Setareh Akhavan, Somaye Norouzi   +3 more
wiley   +1 more source