Results 291 to 300 of about 1,109,166 (346)

Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis

Advanced Science, EarlyView.
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang, Yang Hu, Feiyu Wang, Xintao Peng, Honggang Qi, Yuanyuan Yao, Canyu Zhang, Lijie Zhou, Xuemei Liang, Kang Xu, Cong Zhang, Aifeng Zhang, Chen Chen, Yu Zeng, Chenchen Zhang, Guangming Gan, Xinjian Zhu   +16 more
wiley   +1 more source

Disorders of Sex Development: A Review of Medical and Psychosocial Aspects

Fanti Saktini, Hang Gunawan Asikin, Widodo Sarjana A.S, Agustini Utari   +3 more
openalex   +2 more sources

Epigenetic Targeting of Senescent Cells Prevents the Deleterious Effects of Obstructive Sleep Apnea on Growing Skeleton

Advanced Science, EarlyView.
Chronic intermittent hypoxia induces premature senescence of osteoprogenitor cells in long bone metaphysis via HIF1α‐mediated EZH2‐H3k27me3 downregulation, leading to impaired bone growth. Restoration of H3K27me3 level via UTX inhibition rescues osteogenesis and growth impairment in young mice.
Xiaonan Liu, Peilin Zhang, Zhongyi Su, Yong Feng, Zhenger Zhou, Sa Pang, Yicheng Wang, Jiacheng Hu   +7 more
wiley   +1 more source

The Approach to Patients with Disorders of Sex Development (DSD) in the Era of Precision Medicine: The Careful Use of Terminology. [PDF]

touchREV Endocrinol
Rey RA.
europepmc   +1 more source

Sex, hormones and cerebrovascular function: from development to disorder [PDF]

Adeline Collignon, Laurence Dion‐Albert, Caroline Ménard, Vanessa Coelho‐Santos   +3 more
openalex   +1 more source

NEAT1 Promotes Epileptogenesis in Tuberous Sclerosis Complex

Advanced Science, EarlyView.
The primary neurological manifestations of tuberous sclerosis complex (TSC) are intractable epilepsy and intellectual disability. NEAT1 is differentially expressed in TSC‐related epilepsy and influences neuronal excitability by regulating the PI3K/AKT/mTOR signaling pathway.
Suhui Kuang, Tinghong Liu, Zhirong Wei, Jinshan Xu, Jiayi Han, Jiaqi Wang, Feng Zhai, Yiran Tian, Shuli Liang   +8 more
wiley   +1 more source

Presence of Germ Cells in Disorders of Sex Development: Implications for Fertility Potential and Preservation

, 2016
Courtney Finlayson, Michael K. Fritsch, Emilie K. Johnson, Ilina Rosoklija, Yasmin Gosiengfiao, Elizabeth B. Yerkes, Mary Beth Madonna, Teresa K. Woodruff, Earl Y. Cheng   +8 more
openalex   +2 more sources

Norepinephrine Induces Sertoli Cell Ferroptosis via Receptors Desensitization Causing Stress‐Related Male Reproductive Dysfunction

Advanced Science, EarlyView.
Psychological stress activates the sympathetic–adrenal axis, elevating norepinephrine (NE) and suppressing reproductive hormones, thereby impairing male reproduction. Excess NE overactivates and desensitizes β‐adrenergic receptors (β‐ARs), triggering Sertoli cell ferroptosis and disrupting spermatogenesis.
Lingyu Zhang, Shanfeng Gao, Xiaofan Xiong, Xin Liu, Rufeng Li, Xia Wang, Lin Han, Xuan Xiao, Xiaofei Wang, Wen Li, Yongxia Chang, Yuefeng Du, Juan Yang   +12 more
wiley   +1 more source

Identification and functional analysis of a rare variant of gene DHX37 in a patient with 46,XY disorders of sex development. [PDF]

Mol Genet Genomic Med
Jiang W, Yu J, Mao Y, Tang Y, Cao L, Du Q, Li J, Yang J.   +7 more
europepmc   +1 more source

Androgen insensitivity syndrome in a cohort of Sri Lankan children with 46, XY disorders of sex development

, 2016
K S H De Silva, Nirmala D. Sirisena, H.K. Wijenayaka, M.J.G. Cooray, Rohan W. Jayasekara, Vajira H. W. Dissanayake   +5 more
openalex   +1 more source