Results 51 to 60 of about 956,388 (305)
Molecular Oncology, EarlyView.Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor +2 more
wiley +1 more source
Defining knowledge gaps in preterm birth research: Can biomarkers fill the gaps?
Frontiers in MedicinePreterm birth (PTB) is a syndrome arising from multiple etiologies that manifest as a final common phenotype, delivery before full term. Current knowledge gaps in epidemiologic, basic science, and clinical fields have limited our understanding of this ...
Scott M. Williams +45 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Variable wing venation in Agathiphaga (Lepidoptera: Agathiphagidae) is key to understanding the evolution of basal moths [PDF]
Royal Society Open Science, 2016 Details of the ancestral groundplan of wing venation in moths remain uncertain, despite approximately a century of study. Here, we describe a 3-branched subcostal vein, a 5-branched medial vein and a 2-branched cubitus posterior vein on the forewing of ...
Sandra R. Schachat, George W. Gibbs
doaj +1 more source
Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte +13 more
wiley +1 more source
A GIS-BASED ANALYSIS OF TOURIST DISTRIBUTION IN MONTENEGRO
Zbornik Radova: Geografski institut "Jovan Cvijić", 2019 Montenegro is facing significant changes in tourist turnover. Tourism activity has become increasingly more skewed toward the Montenegrin coastal area, which confirms the concern about regional inequality of tourism.
Marija Cimbaljević +4 more
doaj +1 more source
The Impact of Income Disparity on Financial Regulation [PDF]
, 2014 As part of a symposium on the administrative law of financial regulation, this article shows that there is a two-to-one income disparity between members of the financial industry and their regulators.
Schwarcz, Steven L.
core +3 more sources
Position-specific induction of ectopic limbs in non-regenerating blastemas on axolotl forelimbs. [PDF]
, 2014 Ectopic retinoic acid (RA) has been hypothesized to reprogram the positional identity of cells in developing and regenerating limbs to a single positional value corresponding to the posterior-ventral-proximal (PVPr) position on the limb.
Gardiner, David +2 more
core +2 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective People with epilepsy (PWE) may experience cognitive deficits but fail to undergo formal evaluation. This study compares cognitive status between PWE and healthy controls in the West African Republic of Guinea. Methods A cross‐sectional, case–control study was conducted in sequential recruitment phases (July 2024–July 2025) at Ignace ...
Maya L. Mastick +14 more
wiley +1 more source
Research and Practice in Thrombosis and HaemostasisBackground: Obesity increases the risk of pulmonary embolism (PE) through multiple mechanisms. Objectives: This study examined mortality trends in patients with coexisting PE and obesity.
Aman Goyal +10 more
doaj +1 more source