Results 41 to 50 of about 28,068 (254)

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Optimization of Generator Arrangement for Jin-Zhong HVDC

Zhongguo dianli, 2020
The paper proposes an optimization method which gives the minimum on-service generator number during the low-water and low-load period on the basis that the power system is safe and stable.
Huifan XIE, Yong MEI, Jian ZHOU, Guanghu XU, Lei HUANG, Ming LI, Xiaobin ZHAO, Jian YANG   +7 more
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Research on optimization of power grid load forecasting models based on deep learning

Scientific Reports
Precise forecasting of power grid load is essential for maintaining the stability and efficiency of contemporary energy systems. Traditional statistical and machine learning methods often struggle to capture the nonlinear temporal dependencies and ...
Junhua Hu, Hao Huang, Wenjin Chen, Si Zhang, Daijun Xia, Silei Yao   +5 more
doaj   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Low-Carbon Economic Dispatch of Integrated Energy Systems with Integrated Dynamic Pricing and Electric Vehicles: A Data-Model Driven Optimization Approach

Energies
This paper addresses the critical challenges of multi-stakeholder interest coordination and low-carbon operation in modern power systems, specifically focusing on the interaction among an Integrated Energy System (IES), Electric Vehicle Charging Stations
Jiale Liu, Weisi Deng, Haohuai Wang, Weidong Gao, Qi Mo, Yan Chen   +5 more
doaj   +1 more source

Novel protection method for VSC-HVDC transmission lines

The Journal of Engineering, 2019
The large shunt capacitances on both sides of VSC-HVDC transmission line will block and reflect the travelling waves when a fault occurs on DC cable lines.
Lingtong Jiang, Qing Chen, Lei Wang, Pu Zhao, Yu Zeng, Wudi Huang   +5 more
doaj   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Small signal stability prediction and correction control algorithm for wind power systems based on LightGBM

Frontiers in Energy Research
With the increasing penetration of wind power in electrical power systems, its impact on small signal stability has become increasingly significant. The volatility and uncertainty introduced by wind power integration pose new challenges to power system ...
Yang Fu, Wang Guosong, Xu Yi, Ma Qinfeng, An Su, Chen Junquan   +5 more
doaj   +1 more source