Results 41 to 50 of about 94,390 (312)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Automatic water inventory, collecting, and dispensing unit [PDF]

, 1972
Two cylindrical tanks with piston bladders and associated components for automatic filling and emptying use liquid inventory readout devices in control of water flow.
Hall, J. B., Jr., Williams, E. F.
core   +1 more source

PUTUSAN HAKIM TUNGGAL TENTANG DISPENSASI NIKAH DITINJAU DALAM HIFZ al-NASL MENURUT JASSER AUDA (Studi Kasus Pengadilan Agama Kota Malang Nomor 0344/Pdt.P/2022/PA.Mlg) [PDF]

, 2023
In this study, the researchers investigated the judgment of a single judge on the Dispensation of Marriage Revised in Hifz al-Nasl according to Jasser Auda (Case Study of the Religious Court of the Poor City No. 0344/Pdt.P/2022/PA.Mlg).
Arridho, Hummam
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Statins use amidst the pandemic: prescribing, dispensing, adherence, persistence, and correlation with COVID-19 statistics in nationwide real-world data from Poland

Frontiers in Pharmacology
BackgroundAdherence to medications presents a significant challenge in healthcare. Statins, used in primary and secondary prevention of cardiovascular disease, are of particular importance for public health. The outbreak of the COVID-19 pandemic resulted
Przemysław Kardas, Angelika Kwiatek, Piotr Włodarczyk, Filip Urbański, Beata Ciabiada-Bryła   +4 more
doaj   +1 more source

Programmable models of growth and mutation of cancer-cell populations

, 2011
In this paper we propose a systematic approach to construct mathematical models describing populations of cancer-cells at different stages of disease development.
A.M. Ideta, A.R. Rao, Alberto Policriti, C.J. Mode, D. Gillespie, D. J. Wilkinson, D. Skulj, D.T. Gillespie, Erik de Vink, F. Ciocchetta, F. Ciocchetta, F. Ciocchetta, G. Tanaka, H. Hermanns, Ion Petre, J. R. Norris, L. Bortolussi, L. Bortolussi, L. Bortolussi, L. Bortolussi, L. Bortolussi, Luca Bortolussi, M. Ajmone Marsan, M. Bernardo, M. K. Brawer, M.H.A. Davis, P. Lecca, P.A. Abrahamsson, S.K. Jha, T. L. Jackson, T. Mazza   +30 more
core   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Antibiotic dispensation rates among participants in community-driven health research projects in Arctic Canada

BMC Public Health, 2019
Background Community-driven projects that aim to address public concerns about health risks from H. pylori infection in Indigenous Arctic communities (estimated H.
Kathleen Williams, Amy Colquhoun, Rachel Munday, Karen J. Goodman, CANHelp Working Group   +4 more
doaj   +1 more source

Effect of Implementing a Dashboard With or Without a Best Practice Alert on HLA‐B*58:01 Testing Rates Among Allopurinol Users at VA Medical Centers

Arthritis Care &Research, EarlyView.
Objective The American College of Rheumatology recommends HLA‐B*58:01 allele testing before the initiation of allopurinol, specifically among Asian and African American/Black patients, due to their increased risk for severe hypersensitivity reactions. However, testing rates remain low at many health care facilities.
Abimbola Fadairo‐Azinge, Gabriela Schmajuk, Sristi Sharma, Colleen P. Flanagan, Sara Faghihi‐Kashani, Ning Zhang, Mary A. Whooley   +6 more
wiley   +1 more source