Results 171 to 180 of about 810,508 (318)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Homogenous Agent Wage-Posting Model with Wage Dispersion

In the paper we test a homogenous agent version of the Montgomery's (1991) non-cooperative wage posting model. The inclusion of intrinsic costs, related to the uncertainty when changing the alternative agents are already using, alters the outcome of the ...
Steinbacher, Matjaz, Steinbacher, Mitja, Steinbacher, Matej   +2 more
core  

Numerical Simulation of Atmospheric Pollutant Dispersion on Campus: Impacts of Wind Environment and Newly Constructed Buildings' Height. [PDF]

J Xenobiot
Liao C, Ren L, Xu L, Zhao R, Zhao B, Lin S, Zhang T, Zhuang Y, Gao Y, Ji Y.   +9 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Polarization mode dispersion reduction in spun silica holey fibres

We report the fabrication of a spun holey optical fibre. Our experiments show that the complex air/glass transverse structure can be retained when the preform is spun during the fibre drawing process.
Petrovich, M.N., Fuochi, M., Baggett, J.C., Richardson, D.J., Monro, T.M., Hayes, J.R.   +5 more
core  

Concentration fluctuations in atmospheric dispersion

, 1990
This report summarizes work done at Brunel University under Agreement No.2066/62 from 15 July 1986 to 14 July 1989. The title of the project was Concentration Fluctuations in Atmospheric Dispersion. The report has three principal components. These are:
Hajian, NT, Chatwin, PC
core  

Dispersive Quantization [PDF]

The American Mathematical Monthly, 2010
openaire   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Price Dispersion in the Housing Market: The Role of Bargaining and Search Costs [PDF]

This paper develops a matching model à la Pissarides (2000) in order to explain a basic fact of housing markets: price dispersion. The variance in house prices is basically due to both the ex-ante heterogeneity of the parties (i.e., bargaining power ...
Gaetano Lisi
core  

Accelerating Subcutaneous Drug Development: A Mechanistic Absorption Model for the Open Systems Pharmacology Framework. [PDF]

CPT Pharmacometrics Syst Pharmacol
Pellowe M, Dubbelboer I, Sjögren E.
europepmc   +1 more source