Results 61 to 70 of about 418,870 (216)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Investigation of the relationship between the structural and material composition and band gap characteristics of periodic metal composite beams

Nihon Kikai Gakkai ronbunshu
Vibration reduction strategies based on wave propagation phenomena, such as generating band gaps in periodic structures, are attracting attention in the field of mechanical engineering. This paper investigates how the structural and material compositions
Shoya HONDA, Takahiro TOMIOKA, Yukio MIYASHITA, Ryosuke UJIIE, Hisashi HORI   +4 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Dispersion sensitivity analysis & consistency improvement of APFSDS

Defence Technology, 2017
The purpose of this study is to investigate and quantify some possible sources of dispersion of 120 mm APFSDS tank ammunition both experimentally and numerically.
Sangeeta Sharma Panda, L.K. Gite, A. Anandaraj, R.S. Deodhar, D.K. Joshi, K.M. Rajan   +5 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The influence of organomineral fertilizers on productivity and quality indicators of Italia grape variety and correlation‑statistical analysis of the studied factors

Siberian Journal of Life Sciences and Agriculture
Background. To study the characteristics of chlorophyll accumulation, the increase in leaf surface area, and to evaluate the effectiveness of using the OMU 'Torfoprodukt' preparations on table grapes.
Vladimir A. Boiko, Dmitriy Yu. Belash, Svetlana V. Levchenko, Aleksandr V. Romanov, Anton S. Brichkov, Ludmila A. Voronina, Valentina V. Zharkova   +6 more
doaj   +1 more source

Dispersion Analysis of the XM881APFSDS Projectile

Shock and Vibration, 2001
This study compares the results of a dispersion test with mathematical modeling. A 10-round group of modified 25-mm XM881 Armor Piercing Fin Stabilized Discarding Sabot projectiles was fired from the M242 chain gun into a designated target.
Thomas F. Erline, Brendan J. Patton, Alan F. Hathaway   +2 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source