Results 171 to 180 of about 735,472 (273)

Crystal structure of Schistosoma mansoni cathepsin D1 in complex with a nanobody reveals the conformation of the propeptide‐bound state

open access: yesActa Crystallographica Section D, Volume 82, Issue 2, Page 140-150, February 2026.
Structural characterization of S. mansoni cathepsin D1 in complex with a nanobody reveals the conformation of the propeptide‐bound state and identifies a schistosome‐specific epitope.Schistosoma mansoni cathepsin D1 (SmCD1) has been shown to be an essential enzyme for helminth metabolism due to its role in haemoglobin degradation: a key amino‐acid ...
Kelly L. Parker   +7 more
wiley   +1 more source

Opportunities of patient‐derived organoids in drug development

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 4, Page 939-944, February 2026.
Various model systems are utilised during drug development starting from basic research, moving to preclinical research and development for clinical applications in order to identify new drugs to improve human health. However, there are characteristics of humans that are not captured by established models.
Antonia Büning, Elena Reckzeh
wiley   +1 more source

Quantum-like nonlinear interferometry with frequency-engineered classical light. [PDF]

open access: yesSci Rep
Dalidet R   +4 more
europepmc   +1 more source

Seismic Velocity Variations, Ground Deformation and the Role of Fluids During a Low‐Energy Seismic Swarm

open access: yesGeophysical Research Letters, Volume 53, Issue 2, 28 January 2026.
Abstract On March 9th $9\mathrm{th}$, 2023, three small earthquakes (3.8≤Mw≤4.5) $(3.8\le {M}_{w}\le 4.5)$ occurred near Umbertide (Central Italy), within 4 hours. Analyzing seismic ambient noise in the frequency band 0.1–1 Hz from six seismometers within 20 km of the Mw 4.5, we detect a significant drop in seismic velocity at the time of occurrence of
Eugenio Mandler   +7 more
wiley   +1 more source

Satellite Data Trace Seasonal Freshwater Dispersion in Hudson and James Bays

open access: yesGeophysical Research Letters, Volume 53, Issue 2, 28 January 2026.
Abstract Freshwater dispersal controls stratification, circulation, and biogeochemical processes in Hudson and James Bay (HJB); however, limited field observations hinder understanding of how different freshwater types drive change. This study uses Aqua‐Moderate Resolution Imaging Spectroradiometer and Soil Moisture and Ocean Salinity‐Microwave Imaging
Atreya Basu   +9 more
wiley   +1 more source

Electronic Hong Ou Mandel interferences to unveil the 2/3 fractional quantum Hall edge channel dynamics. [PDF]

open access: yesNat Commun
De A   +7 more
europepmc   +1 more source

Tracking Subsurface Changes via Frequency Shifts in Volcanic Tremor Spectral Lines: Observations From Mt Etna

open access: yesGeophysical Research Letters, Volume 53, Issue 2, 28 January 2026.
Abstract Episodes of volcanic tremor provide valuable insights into the dynamics of subsurface processes at active volcanoes. Previous studies have suggested that evolving tremor properties may relate to changes in the stress conditions of the plumbing system. However, a strong causative link has remained elusive.
A. S. Yates   +6 more
wiley   +1 more source

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