Results 61 to 70 of about 129,267 (266)

Properties and oil displacement efficiency of emulsified viscosity reducer

Youqi dizhi yu caishoulu
To solve the problem of unclear comparison and optimization methods for viscosity reducers in the development of chemical viscosity reduction for heavy oil， a quantitative relationship between the properties of viscosity reducers and their oil ...
WEI Chaoping, SHU Ningkai, LI Wei, WU Guanghuan, ZHAO Hongyu, ZHONG Liguo   +5 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Displacement-Invariant Cost Computation for Efficient Stereo Matching

, 2020
Although deep learning-based methods have dominated stereo matching leaderboards by yielding unprecedented disparity accuracy, their inference time is typically slow, on the order of seconds for a pair of 540p images. The main reason is that the leading methods employ time-consuming 3D convolutions applied to a 4D feature volume.
Zhong, Yiran, Loop, Charles, Byeon, Wonmin, Birchfield, Stan, Dai, Yuchao, Zhang, Kaihao, Kamenev, Alexey, Breuel, Thomas, Li, Hongdong, Kautz, Jan   +9 more
openaire   +2 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Study on Influence Law of Borehole Rugosity on Cementing Displacement Efficiency

Shiyou jixie, 2016
The displacement efficiency of cementing annulus cement slurry has crucial influences on preven-ting drilling fluid channeling, guaranteeing cementing quality and improving cement ring sealing effect, while the borehole rugosity is an important factor ...
Fang Chunfei, Zhou Shiming, Li Gensheng, Fu Jiasheng   +3 more
doaj  

Study on Flow in Fractured Porous Media Using Pore-Fracture Network Modeling

Energies, 2017
Microscopic flow in fractured porous media is a typical problem for the exploitation of tight reservoirs. The rapid-flow in the fractured porous-media is of great significance to efficient and continuous oil/gas exploitation.
Haijiao Liu, Xuhui Zhang, Xiaobing Lu, Qingjie Liu   +3 more
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

A Dynamic Network Model for Forced Imbibition Considering Competition Between Main‐Meniscus Flow and Corner Flow

Water Resources Research
The pore‐scale interfacial dynamics including main‐meniscus flow and corner flow usually occurs in heterogeneous porous media and significantly affects the macroscopic multiphase flow process.
Wenbo Gong, Wenhai Lei, Tian Tian, Jiangtao Zheng, Yang Liu, Yuedi Wang, Yang Ju, Moran Wang   +7 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source