Results 221 to 230 of about 2,383,636 (277)

Sortase-mediated generation of various macrocyclic peptide scaffolds from low-reactivity electrophilic substrates. [PDF]

Chem Sci
Xia ZM, Wei HM, Xue JH, Sun YN, Wan XC, Tong HR, Zhou L, Shi P, Fang GM, Tian C.   +9 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Predicting smartphone battery time-to-empty(TTE) on an open-source PinePhone platform: A modular electro-thermal continuous-time model. [PDF]

PLoS One
Long Y, Tian S, Liu X, Peng X.
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Correction to "Half-Pipe Melt Electrowritten Scaffolds Support Engineering of an Immunocompetent Hydrogel-Embedded Intestine-on-a-Chip". [PDF]

Adv Sci (Weinh)
europepmc   +1 more source

Charge trapping model for investigating oil backflow mechanism in electrowetting display pixels. [PDF]

Sci Rep
Zhang T, Zhu H, Liu L, Li W, Wang X, Tang B, Yuan D, Zeng W, Umar A, Ibrahim AA, Zhou G.   +10 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Wearable headset-assisted fluoroscopic visualization during complex endovascular aortic repair. [PDF]

J Vasc Surg Cases Innov Tech
Yamanouchi D.
europepmc   +1 more source

Mapping Concepts Onto Linguistic Structure: The Case of Animacy. [PDF]

Cogn Sci
Fukumura K.
europepmc   +1 more source