Results 191 to 200 of about 1,020,740 (239)

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

open access: yesSmart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang   +8 more
wiley   +1 more source

Artemia salina Toxicity Assay: Standardization in a 24‐Well Microplate

open access: yesEnvironmental Toxicology, EarlyView.
ABSTRACT Bioassays with Artemia sp. are widely used in aquatic, environmental, and human toxicology as an initial tool to investigate the toxicity of plant extracts, isolated compounds, drugs, and products of natural or synthetic origin. These assays allow for the estimation of the median lethal concentration (LC50) and guide subsequent studies in ...
Matheus Pires Miranda   +4 more
wiley   +1 more source

From Consumer Plastics to Aquatic Toxicants: Oxidative and Endocrine Effects of Microplastics on Fathead Minnow (Pimephales promelas) Larvae

open access: yesEnvironmental Toxicology, EarlyView.
ABSTRACT Secondary microplastics (MPs) from single‐use consumer products are rapidly becoming one of the most persistent and widespread pollutants of our time. Freshwater systems act as early sinks for MPs where fragmentation and additive leaching expose aquatic life to a broad spectrum of toxic compounds.
Alisha M. Janiga‐MacNelly   +3 more
wiley   +1 more source

Two‐Dimensional Materials For Lateral Flow Assays: A Critical Review of Functional Roles and Translational Challenges

open access: yesVIEW, EarlyView.
2D nanosheets, with large surface area, excellent optical/electrical properties, and high specificity, combine with lateral flow assay strips to enable rapid, readable detection, boosting the strips’ development and applications. Abstract Lateral flow assays (LFAs) are widely used for point‐of‐care diagnostics, but their detection capability remains ...
Weimin Xu   +11 more
wiley   +1 more source

Surface Micro‐Discharge Plasma for Multiple Teeth Bleaching: Efficacy, Mechanism and Safety

open access: yesHigh Voltage, EarlyView.
ABSTRACT Hydrogen peroxide (H2O2) is the commonly‐used bleaching chemical in clinical practice, but its excessive concentrations can cause tooth damage. Atmospheric pressure cold plasma is considered a promising new technique for tooth bleaching. Surface micro‐discharge (SMD) devices can generate large‐scale plasma, which holds potential for treating ...
Ruike Chen   +7 more
wiley   +1 more source

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