Results 131 to 140 of about 1,284,685 (310)

Hepatocyte PIEZO1 Negatively Regulates Lipogenesis and Ameliorates MASLD by Sensing Membrane Tension and Activating AMPK

open access: yesAdvanced Science, EarlyView.
Hepatocytes are subjected to increased membrane tension along with lipid accumulation. Loss of PIEZO1 exacerbates high‐fat diet‐induced MASLD in mice. Activation of PIEZO1 alleviates high‐fat diet‐induced MASLD in mice. PIEZO1 negatively regulates de novo lipogenesis through activation of CaMKK2‐AMPK pathway. ABSTRACT Liver is a central organ for lipid
Hui Chen   +14 more
wiley   +1 more source

Deconstructing Ethnic Identity of Chinese Children in Northern Ireland

open access: yesForum: Qualitative Social Research, 2006
This paper focuses on two groups of sub-ethnic Chinese children respectively migrating from Mainland China and Hong Kong to Northern Ireland. It examines their cultural narratives surrounding topics of their country of origin, their adopted society in ...
Monica Feng-Bing
doaj  

Machine Learning for Green Solvents: Assessment, Selection and Substitution

open access: yesAdvanced Science, EarlyView.
Environmental regulations have intensified demand for green solvents, but discovery is limited by Solvent Selection Guides (SSGs) that quantify solvent sustainability. Training a machine learning model on GlaxoSmithKline SSG, a database of sustainability metrics for 10,189 solvents, GreenSolventDB is developed. Integrated with Hansen solubility metrics,
Rohan Datta   +4 more
wiley   +1 more source

Habits and Dispositions in Frank Ramsey’s Philosophy

open access: yesEuropean Journal of Analytic Philosophy
This paper examines Ramsey’s use of the concepts of habit and disposition, challenging the common interpretation that he employs them interchangeably in his theory of belief.
Alice Morelli
doaj   +1 more source

A Perspective on Interactive Theorem Provers in Physics

open access: yesAdvanced Science, EarlyView.
Into an interactive theorem provers (ITPs), one can write mathematical definitions, theorems and proofs, and the correctness of those results is automatically checked. This perspective goes over the best usage of ITPs within physics and motivates the open‐source community run project PhysLean, the aim of which is to be a library for digitalized physics
Joseph Tooby‐Smith
wiley   +1 more source

Insights into the Metabolism, Disposition, and Quantitative Profile of mGlu5 NAM AE90015 with Metabolite Identification and a Novel Integration Method

open access: yesMolecules
AE90015 is a highly specific and effective negative allosteric modulator (NAM) for the human mGlu5 receptor, showing significant promise for treating Parkinson’s disease.
Zhiyang Zack Zou   +3 more
doaj   +1 more source

Do Farmers Exhibit Disposition Effect?: Evidence from Grain Marketing [PDF]

open access: yes
disposition effect, grain marketing, Agribusiness, Institutional and Behavioral Economics, Marketing,
Mattos, Fabio
core   +1 more source

Self‐Nitriding Nanostructured Transition Metal Nitrides in Architected‐Carbon Matrices: Unveiling Mechanisms and Advancing Performance in Lithium‐Sulfur Pouch Cells

open access: yesAdvanced Science, EarlyView.
Imidazolium PIL nanoparticles, as an N‐rich template and morphology director, enable a colloidal self‐nitriding route to TMNs (VN, Mo2N) within controlled solid/hollow carbon architectures. As sulfur hosts/additives, TMNs accelerate Li–S redox kinetics and support high‐loading cathodes.
Yael Rodriguez Ayllon   +14 more
wiley   +1 more source

Comment se fait l’incorporation ? Brèves considérations

open access: yesSociologies, 2020
Sociologists have been more interested in (1) what incorporates and (2) what the incorporation does than (3) how it is done. This theoretical, synthetic and multidisciplinary article provides some answers to the question : how is the incorporation done ?
Tony Orival
doaj  

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

open access: yesAdvanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård   +19 more
wiley   +1 more source

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