Results 61 to 70 of about 13,427 (290)

No evident association between efavirenz use and suicidality was identified from a disproportionality analysis using the FAERS database

Journal of the International AIDS Society, 2014
Objective To assess the potential association of selected antiretrovirals (ARVs), including efavirenz, with suicidality. Design Retrospective analysis of the Food and Drug Administration Adverse Event Reporting System (FAERS), by performing a Multi‐Item ...
Andrew A Napoli, Jennifer J Wood, John J Coumbis, Amit M Soitkar, Daniel W Seekins, Hugh H Tilson   +5 more
doaj   +1 more source

Potentials and Impediments to Universal, School-based Screening for Behavioral and Emotional Risk: A Critical Discourse Analysis of Current Case Law [PDF]

, 2011
Disproportionality in special education is a long-standing issue. Some scholars have proposed group or universal screening for emotional and behavioral risk in schools as a method of addressing disproportionality. Considering previous case law, questions
Gardner, Natasha D.
core   +1 more source

Age‐related differences in hydroxychloroquine‐associated adverse events: A pharmacovigilance study based on the FDA Adverse Event Reporting System

British Journal of Clinical Pharmacology, EarlyView.
Aims This real‐world pharmacovigilance study utilizes FDA Adverse Event Reporting System (FAERS) data (2004–2024) to characterize age‐related disparities in hydroxychloroquine (HCQ)‐associated adverse events (AEs), addressing gaps in age‐stratified risk assessment. Methods Disproportionality analysis (reporting odds ratios, RORs) and parametric Weibull
Guanghan Sun, Jingrong Yang, Lei Wan, Xia Xu, Jing Wang   +4 more
wiley   +1 more source

The real-world safety evaluation of the selective NaV1.8 inhibitor suzetrigine: disproportionality analysis and flexible empirical bayes signals from FAERS with external triangulation

Frontiers in Pharmacology
BackgroundSuzetrigine (Journavx; VX-548), the first selective NaV1.8 voltage-gated sodium channel inhibitor approved by the FDA on 30 January 2025, represents a novel non-opioid option for moderate-to-severe acute pain.
Kun Lai, Kun Lai, Lan Luo, Fuzhao Zhang, Eugenie Sin Sing Tan, Anand Gaurav, Jianghua Zheng, Jianghua Zheng, Chung Keat Tan   +8 more
doaj   +1 more source

Evaluating the (comparative) safety profile of the novel oral polio vaccine type 2 using individual case safety reports in VigiBase

British Journal of Clinical Pharmacology, EarlyView.
Aim Novel oral polio vaccine type 2 (nOPV2) was used under the WHO emergency use listing for circulating vaccine‐derived polio virus (cVDPV) outbreaks from 2021 to 2023. We assessed nOPV2 adverse events following immunization (AEFIs) and compared its safety profile to other vaccines using VigiBase.
Comfort Kunak Ogar, Malede Mequanent Sisay, Leonardo Roque‐Pereira, Christine Leopold, Patrick C. Souverein, Aukje K. Mantel‐Teeuwisse, Marie L. De Bruin   +6 more
wiley   +1 more source

Drug-specific safety signal prioritization of antibody-drug conjugates in breast cancer: integrating FAERS pharmacovigilance, machine learning, and clinical contextualization

Frontiers in Pharmacology
BackgroundAntibody–drug conjugates (ADCs) are increasingly used across breast cancer subtypes, but their postmarketing safety-reporting patterns differ across agents and are difficult to interpret across spontaneous-reporting and clinical settings.
Yuhan Tang, Shaochun Liu, Yingze Zhu, Linlin Fan, Xiaoxi Han, Wenjie Ma, Haolu Zhang, Zhiqi Sui, Hui Pang, Wenhui Zhao   +9 more
doaj   +1 more source

Case‐malformed signal detection and prioritisation using EUROmediCAT data for pharmacovigilance in pregnancy

British Journal of Clinical Pharmacology, EarlyView.
Aim Many women take medications during pregnancy. However, the risk to the fetus from most medications is uncertain. Congenital anomalies are one of the leading causes of infant death and contribute to long‐term disability. Signal detection methods can be used to systematically identify possible medication–anomaly associations that require further ...
Hannah Johnson, Helen Dolk, Maria Loane, Christine Damase‐Michel, Joanne Given, Hedvig Nordeng, Jorieke E. H. Bergman, Iain Carey, Elly Den Hond, Ester Garne, Florence Rouget, Lea Bruneau, Isabelle Monier, Anke Rissmann, Mary O'Mahony, Miriam Gatt, Renée Lutke, Joanna Sichitiu, Elisa Ballardini, Alessio Coi, Clara Cavero Carbonell, David Tucker, Joan Morris   +22 more
wiley   +1 more source

Disproportionality, Multipartism, and Majority Victories

, 1994
This chapter discusses the main political consequences of an electoral system. These are the effects of the electoral system on the proportionality and disproportionality of the electoral outcomes and their effects on the party system, especially the ...
Arend Lijphart
core   +1 more source

Lessons from local area special educational needs and disability inspections: A content analysis of Ofsted and Care Quality Commission outcome letters

British Educational Research Journal, EarlyView.
Abstract The growing concern about demand for, and provision of, support for children and young people with special educational needs and disabilities (SEND) has led the English government to announce a review of the system, which many describe as being in crisis.
Ariadna Albajara Sáenz, Isaac Winterburn, Jacob Matthews, Anne‐Marie Burn, Tamsin Ford, Jennifer Saxton   +5 more
wiley   +1 more source

IndElec: A Software for Analyzing Party Systems and Electoral Systems

Journal of Statistical Software, 2011
IndElec is a software addressed to compute a wide range of indices from electoral data, which are intended to analyze both party systems and electoral systems in political studies.
Francisco Ocaña, Pablo Oñate
doaj