Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek +2 more
wiley +1 more source
Retraction notice to "Computational analysis of anti-cancer drug hydroxyurea adsorption on nanocages of gold, silver and copper: SERS and DFT assessment" [Heliyon 10 (2024) e24475]. [PDF]
Kumaran S +3 more
europepmc +1 more source
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Retraction notice to "Bibliometric analysis of the association between periodontal disease and cardiovascular disease" [Heliyon 10 (2024) e32065]. [PDF]
Jiang H +7 more
europepmc +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Retraction notice to "Development and validation of a clinical prediction model for early ventilator weaning in post-cardiac surgery" [Heliyon 10 (2024) e28141]. [PDF]
Xie RC +8 more
europepmc +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Retraction notice to "Advances in biodegradable materials: Degradation mechanisms, mechanical properties, and biocompatibility for orthopedic applications" [Heliyon 10 (2024) e32713]. [PDF]
Hussain M +5 more
europepmc +1 more source
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
Retraction notice to "Nutritional and bioactive properties and antioxidant potential of <i>Amaranthus tricolor</i>, <i>A. lividus</i>, <i>A viridis,</i> and <i>A. spinosus</i> leafy vegetables" [Heliyon 10 (2024) e30453]. [PDF]
Sarker U +8 more
europepmc +1 more source

