A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti +3 more
wiley +1 more source
Comments on 'Testing VPIN on Big Data - Response to Reflecting on the VPIN Dispute'
Torben G. Andersen, Oleg Bondarenko
openalex +1 more source
The Dispute Tree and the Legal Forest
C. Albiston, L. Edelman, Joy Milligan
semanticscholar +1 more source
Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi +7 more
wiley +1 more source
Personal medical data protection of mobile pharmacy apps in China 2025: scale development and content analysis. [PDF]
Chen T, Guo R.
europepmc +1 more source
Dispute Resolutions under the Li-china (里中) System during the earlier half of Ming Dynasty : An Analysis based on Hui-chou (徽州) Documents [PDF]
Yoshiaki NAKAJIMA
openalex
It's All Downhill from Here: How the Nation's Dispute with Clean Water Act Jurisdiction Is Solved
Spencer H. Newman
openalex +1 more source
Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde +3 more
wiley +1 more source
The nature of depression and the biomedical model: ten questions in search of an answer. [PDF]
Fountoulakis KN.
europepmc +1 more source

