Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Judicialization in international security: A theoretical concept and some preliminary evidence [PDF]
Many claim a process of judicialization of international dispute settlement procedures is taking place. In order to capture this ongoing process we introduce an analytical framework to assess the degree of judicialization of international dispute ...
Mondré, Aletta, Zangl, Bernhard
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Jurnal Ilmiah Hubungan Internasional, 2014 : This article examines the role of ASEAN's norms in managing dispute over the South China Sea. ASEAN shares the beliefs that the settlement of differences or disputes by peaceful means and the abandonment of the threat or use of force are necessary to ...
Ratih Indraswari
doaj +1 more source
Interconnected principles of ocean governance through science-policy integration under the judgements of the international dispute settlement bodies. [PDF]
Sci Prog, 2023 Zhang S, Butt MJ, Zulfiqar K.
europepmc +1 more source
Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity
Molecular Oncology, EarlyView.Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek +2 more
wiley +1 more source
EU Enlargement in Disregard of the Rule of Law: A Way Forward Following the Unsuccessful Dispute Settlement Between Croatia and Slovenia and the Name Change of Macedonia. [PDF]
Hague J Rule Law, 2022 Basheska E.
europepmc +1 more source
Trade dispute settlement mechanisms: the WTO dispute settlement understanding in the wake of the GATT [PDF]
A critical feature of the GATT Uruguay Round negotiations was the establishment of a new and more effective system of dealing with international trade disputes, known as the WTO Dispute Settlement Understanding (DSU). The original GATT dispute settlement
R A Read
core +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
The choice of method in civil dispute resolution and decision-making factors [PDF]
Zbornik Radova Pravnog Fakulteta u Nišu, 2020 The disputes arising as a consequence of the violation of subjective civil rights can be resolved through litigation, settlement, alternative dispute resolution, or some other method (compromise, force, etc.). By choosing the method in which they wish to
Petrović Danijela
doaj