Results 51 to 60 of about 3,902 (303)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

ASEAN vs. WTO DSM: Overcoming Jurisdiction Issues to Encourage Regional Trade Agreements’ System Efficacy

open access: yesYuridika, 2019
Dispute settlement mechanism holds an important role in upholding the rights and obligations of member countries under any agreements signed by ASEAN members as well as to resolve any dispute between Members, therefore, AFTA has its own dispute ...
Wisawawit Udomjitpittaya   +1 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Brexit: Towards an ‘EFTA-like’ dispute settlement mechanism. CEPS Commentary, 31 August 2017 [PDF]

open access: yes, 2017
In its position paper on the jurisdiction of the CJEU, the UK is flirting with an EFTA-like solution, but it does not spell out the inherent consequences of such a future dispute settlement model.
Van der Loo, Guillaume   +1 more
core  

THE URGENCY AND FINANCIAL SERVICES SECTOR DISPUTE SETTLEMENT MECHANISM THROUGH ALTERNATIVE DISPUTE SETTLEMENT INSTITUTIONS

open access: yes, 2022
Settlement of disputes that occur between Consumers and Financial Services Providers can not only be done through litigation (court) but there are also other options through Alternative Dispute Resolution (non-litigation) channels which are commonly ...
Aprinisa
core   +1 more source

Prospects of Reform of the WTO Dispute Settlement Mechanism

open access: yes, 2011
In a context of economic globalization, the WTO emerged within the multilateral trading system as an international organization settling intergovernmental trade disputes.
El Khoury, Maya
core   +2 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Effective dispute settlement as a mechanism of economic attractiveness

open access: yesMATEC Web of Conferences, 2018
Commercial disputes the number of which is growing every year can cause economic imbalance if a country doesn’t obtain ADR (Alternative disputes resolution) technologies and methods implementation experience.
Zaitseva Larisa
doaj   +1 more source

Special and Differential Treatment: A New Factor Explaining LDC Engagement with the WTO Dispute Settlement System?

open access: yesInternational Review of Law, 2019
The factors explaining the lack of participation and engagement by Least Developed Countries (LDCs) in the World Trade Organization (WTO) dispute settlement mechanism (DSU) have been the subject of much academic discourse. This paper posits the existence
رونالد ويلش
doaj   +2 more sources

HOW THE TRADE DISPUTES BETWEEN EU AND UKRAINE WILL BE SETTLED UNDER THE EU-UKRAINE ASSOCIATION AGREEMENT? [PDF]

open access: yesLex Portus, 2017
The Article deals with the Dispute Settlement Mechanism (DSM) under the EU‐Ukraine Association Agreement setting out the main procedural ele‐ ments of the DSM and comparing them with the DSM of the WTO.
Yuriy Rudyuk
doaj  

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