Results 41 to 50 of about 3,205 (300)
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
WTO ::Institutions and dispute settlement /
, 2022 Two of the greatest achievements of the Uruguay Round were the establishment of the World Trade Organization (WTO) as - compared to the GATT - a fully-fledged international organization and the creation of a new, uniform and binding dispute settlement ...
Kaiser, Karen. +2 more
core +1 more source
WTO Dispute Settlement: Can We Go Back Again?
AJIL Unbound, 2019 The world's twenty-year experiment with a rule-based international trading order is most likely ending. Trade wars are raging again for the first time in two decades as World Trade Organization (WTO) members unilaterally impose and counterimpose ...
Rachel Brewster
doaj +1 more source
FEBS Open Bio, EarlyView.This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source
PEMBERDAYAAN LEMBAGA MEDIASI DALAM PENYELESAIAN SENGKETA DI BIDANG PERTANAHAN
Masalah-Masalah Hukum, 2012 Operation of mediating institutions in order to perform its functions is part of the workings of the legal system that is affected by the component structure, substance and culture.
Sukresno Sukresno
doaj +1 more source
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
The Power of Law or the Law of Power?
Meridiano 47, 2017 This article criticizes the approach liberal scholars in International Relations and Law have provided to the Dispute Settlement Understanding of the World Trade Organization. Liberal theorists erroneously believe the enhanced legalization of the system,
Igor Abdalla Medina de Souza
doaj
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
Revista Chilena de Derecho, 2006 El Acuerdo de Asociación entre Chile y la Unión Europea contempla un capítulo sobre el mecanismo de solución de controversias, que se superpone al establecido en el Entendimiento sobre Solución de Diferencias de la Organización Mundial del Comercio. Para
Cristián Delpiano Lira
doaj