Results 71 to 80 of about 885,017 (286)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Production disruption management for R/M integrated supply chain using system dynamics methodology

International Journal of Sustainable Engineering, 2017
The impacts of production disruption in Remanufacturing/Manufacturing (R/M) integrated supply chain on the sales and the methods of production disruption management were studied. A system dynamics model for the R/M integrated supply chain with production
Qiaolun Gu, Tiegang Gao
doaj   +1 more source

Social Entrepreneurship Management In Marketer Village In Era Disruption

JPBM (Jurnal Pendidikan Bisnis dan Manajemen), 2019
The study aims to explain that the social entrepreneurship management of Marketer Village reviewed from marketing management, operational management, human resource management, and financial management.
Puji Novita Sari, Susmy Lianingsih, Yulia Sandra Sari   +2 more
doaj   +1 more source

How do principles for human-centred automation apply to Disruption Management Decision Support? [PDF]

, 2016
While automation of signal and route setting is routine, the use of automation or decision support in disruption management processes is far less common. Such support offers significant advantages in optimising re-planning of both timetable and resources
Dadashi, Nastaran, Golightly, David
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Disruption management in single wagonload transport

Transportation Research Interdisciplinary Perspectives
In highly utilised rail networks, disruptions can quickly have extensive impact on overall network performance, significantly affecting the reliability and efficiency of transport chains.
Maurice Krauth, Daniel Haalboom, Henning Preis, Nikola Bešinović   +3 more
doaj   +1 more source

Traumatic Spondylopelvic Dissociation: A Report of Two Cases of Spondylolisthesis at L5-S1 and Review of Literature. [PDF]

, 2015
Study Design Retrospective chart review and review of literature. Objective Few case reports of traumatic L5-S1 displacement have been presented in the literature.
Gupta, Munish, Klineberg, Eric, Mallon, Zachary, Patel, Ravi, Robbins, Michael, Roberto, Rolando   +5 more
core   +2 more sources

Navigating new norms: a systematic review of factors for the development of effective digital tools in higher education

FEBS Open Bio, EarlyView.
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman, Jessica Haines, Connie Pritchard, Stephen Rutherford, Nigel Francis   +4 more
wiley   +1 more source

A Quantitative Model of Supply Chain Disruption Propagation Dynamics

Engineering Proceedings
Supply chain disruptions caused by natural disasters and human-made incidents have inflicted substantial losses on numerous companies. The management of supply chain risks, including disruption risk, has garnered significant attention from both academia ...
Shudong Liu, Shili Xiang, Lu Wang
doaj   +1 more source