Results 111 to 120 of about 140,191 (290)

Data visualization and dimensionality reduction methods for disruption prediction at ASDEX Upgrade [PDF]

, 2013
The. physical phenomena leading to disruptions are very. complex and non linear and the present state of knowledge is not sufficient to explain the intrinsic structure of the data of interest.
FANNI, ALESSANDRA, ALEDDA, RAFFAELE, Pautasso G., CANNAS, BARBARA, SIAS, GIULIANA, PAU, ALESSANDRO   +5 more
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Hybrid deep learning architecture for general disruption prediction across tokamaks [PDF]

In this paper, we present a new deep learning disruption prediction algorithm based on important findings from explorative data analysis which effectively allows knowledge transfer from existing devices to new ones, thereby predicting disruptions using ...
J.X. Zhu, C. Rea, K. Montes, R.S. Granetz, R. Sweeney, R.A. Tinguely
core   +1 more source

Machine Learning Models for Estrogen Receptor Bioactivity and Endocrine Disruption Prediction. [PDF]

Environ Sci Technol, 2020
Zorn KM, Foil DH, Lane TR, Russo DP, Hillwalker W, Feifarek DJ, Jones F, Klaren WD, Brinkman AM, Ekins S.   +9 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Correlation between General Health with Life Expectancy and Quality of Life in Patients with leukemia

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2017
Background and Objectives: Cancer is one of the most important diseases of the present century and the second cause of death. This study aimed to determine the correlation between general health with life expectancy and quality of life in Patients with ...
Farhad Kahrazee, Behzad Rigi Kooteh, Amir Akbari Esfahani   +2 more
doaj  

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Disruption prediction at JET [Joint European Torus] [PDF]

The sudden loss of the plasma magnetic confinement, known as disruption, is one of the major issue in a nuclear fusion machine as JET (Joint European Torus), Disruptions pose very serious problems to the safety of the machine.
Milani, Federico
core  

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

MHD, disruptions and control physics: Chapter 4 of the special issue: on the path to tokamak burning plasma operation [PDF]

In this chapter, we review the progress in MHD stability, disruptions and control in magnetic fusion research that has occurred over the past (more than) one and a half decades since the publication by Hender et al in 2007 on the same topic as part of ...
Ferraro, N., H. Reimerdes, Berkery, J., J. Graves, Matsuyama, A., I. Bandyopadhyay, E. Nardon, E.M. Hollmann, Myers, C., L.R. Baylor, S.C. Jardin, Lukash, V., Maraschek, M., Dubrov, M., B. Cannas, L. Bardóczi, G.A. Rattá, Granetz, R., N.M. Ferraro, Igochine, V., N.C. Logan, Kavin, A., Artola, F., Maget, P., Maraschek, M. ; https://orcid.org/, Wang, H. H., V. Yanovskiy, Granucci, G., Hoelzl, M., A. Fanni, Fitzpatrick, R., Sieglin, B. ; https://orcid.org/, H. Zohm, V.E. Lukash, Goodman, T., Sias, G., Piron, L., O. Kudláček, C. Reux, C. Sovinec, G. Pautasso, N. Eidietis, Isayama, A., Reimerdes, H., Pautasso, G., F. Villone, Z.Y. Chen, S. Jachmich, Sieglin, B., G. Rubinacci, Pucella, G., R. Roccella, Baylor, L., C. Myers, A.H. Boozer, D. Orlov, Rubinacci, G., Gribov, Y., G. Kim, A. Matsuyama, Boozer, A., Jachmich, S., D.A. Humphreys, Y. Gribov, Villone, F., A. Pau, A.A. Kavin, Hu, Q., Igochine, V. ; https://orcid.org/, Ratta, G., the ITPA MHD, Disruption and Control Topical Group, H.-H. Wang, Sauter, O., M. Lehnen, Chen, Z., Khayrutdinov, R., Hoelzl, M. ; https://orcid.org/, Lehnen, M., de Baar, M., T. Goodman, S. Gerasimov, F. Maviglia, Sovinec, C., Yanovskiy, V., Humphreys, D., Maviglia, F., J.E. Menard, R. Sweeney, Bandyopadhyay, I., Gerasimov, S., A. Gude, In, Y., M. Dubrov, Esposito, B., P. Maget, G. Sias, Pustovitov, V., Sheikh, U., D. Shiraki, Markovic, T., R. Fitzpatrick, Sweeney, R., Y. In, Rea, C., Bardoczi, L., L. Piron, Park, J., Reux, C., Park, J. K., Q. Hu, Y. Liu, Hu, W., C. Paz-Soldan, Shiraki, D., M. de Baar, Isernia, N., M. Hoelzl, Eidietis, N., Menard, J., Paz-Soldan, C., R. Granetz, Wang, H., Zohm, H. ; https://orcid.org/, Orlov, D., J.W. Berkery, Graves, J., H. Strauss, Kudlacek, O. ; https://orcid.org/, S.M. Yang, Cannas, B., N. Isernia, B. Esposito, T. Markovic, Hollmann, E., G. Granucci, Logan, N., M. Kong, Kim, G., Gude, A., Strauss, H., J.-K. Park, Fanni, A., W. Hu, A. Isayama, Liu, Y., Yang, S., V. Igochine, G. Pucella, Sabbagh, S., Baar, M., O. Sauter, Jardin, S., Nardon, E., Kudláček, O., Kong, M., V.D. Pustovitov, C. Rea, Roccella, R., Y. Sun, M. Maraschek, B. Sieglin, Pau, A., S.A. Sabbagh, R.R. Khayrutdinov, Sun, Y., U. Sheikh, F.J. Artola, Zohm, H.   +167 more
core   +2 more sources