Results 101 to 110 of about 1,326,556 (316)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post +3 morewiley +1 more sourceConserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park +4 morewiley +1 more sourceNon-linear MHD modelling of transients in tokamaks: a review of recent advances with the JOREK code
Nuclear FusionTransient magneto-hydrodynamic (MHD) events like edge localized modes (ELMs) or disruptions are a concern for magnetic confinement fusion power plants. Research with the MHD code JOREK towards understanding control of such instabilities is reviewed here ...M. Hoelzl, G.T.A. Huijsmans, F.J. Artola, E. Nardon, M. Becoulet, N. Schwarz, A. Cathey, S.J.P. Pamela, K. Aleynikova, F. Antlitz, V. Bandaru, H. Bergström, A. Bhole, T. Bogaarts, D. Bonfiglio, F. Cipolletta, T. Driessen, L. Edes, S. Futatani, G. Hao, F. Hindenlang, I. Holod, D. Hu, S. Hu, N. Isernia, H. Isliker, S.K. Kim, M. Kong, S. Korving, L. Kos, I. Krebs, S.J. Lee, Y.C. Liang, Z. Liang, S.J. Liu, Z.X. Lu, L. Meier, L. Messfeldt, V. Mitterauer, N. Nikulsin, B. Nkonga, R. Ramasamy, J. Reinking, C. Rogge, G. Rubinacci, K. Särkimäki, T. Smits, C. Sommariva, R. Sparago, K. Strien, M. Szucs, W. Tang, J. van Tongeren, F. Vannini, S. Ventre, F. Villone, C. Wang, L. Wang, F. Wieschollek, F. Wouters, J. Zielinski, H. Zhang +61 moredoaj +1 more sourceMicrobiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille +3 morewiley +1 more sourceStructure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.Alex J. Vecchiowiley +1 more sourceDiscerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.Kati Fischermanns, Johannes Broichhagenwiley +1 more sourceResults from the last DD and DT JET campaigns in the framework of the EUROfusion Tokamak Exploitation Work Package activity
Nuclear FusionJET, the only tokamak capable of operating with deuterium–tritium (D–T) fuel (since TFTR was shutdown in 1999), has provided essential experimental data to support ITER and DEMO design and operation.N. Vianello, E. Joffrin, M. Baruzzo, A. Hakola, A. Kappatou, D. Keeling, B. Labit, E. Tsitrone, M. Wischmeier, J. Adamek, M. Agostini, C. Albert, F.C.P. Albert Devasagayam, G. Alberti, F. Albrecht, S. Aleiferis, E. Alessi, J. Alhage, S. Allan, M. Alonzo, S. An, G. Anastasiou, E. Andersson-Sunden, C. Angioni, F. Antlitz, Y. Antonenas, G.M. Apruzzese, M. Ariola, J.F. Artaud, W. Arter, A. Ash, Y. Asnis, O. Asztalos, L. Aucone, M.H. Aumeunier, F. Auriemma, C. Avanzato, J. Ayllon-Guerola, E. Aymerich, A. Baciero, F. Bairaktaris, P. Balázs, L. Balbinot, I. Balboa, A. Balestri, O. Bardsley, A. Battey, T. Bauer, C. Baumann, M.G. Bergmann, H. Bergstroem, E. Bernard, M. Bernert, A. Biancalani, R. Bianchetti Morales, R. Bilato, P. Bilkova, W. Bin, G. Birkenmeier, R. Bisson, S. Blackmore, F. Blaise, V. Bobkov, A. Boboc, A. Bock, P. Bohm, T. Bolzonella, L. Bonalumi, D. Bonfiglio, M. Bonisolli, D. Borodin, I. Borodkina, T. Bosman, C. Bottereau, L. Bramucci, B. Brandström, S. Brezinsek, D. Brida, M. Brix, F. Brochard, B. Brown, A. Bruncrona, D. Brunetti, J. Bryant, J. Buermans, H. Bufferand, A. Burckhart, J. Cai, J. Caloud, G. Camera, F. Cani, B. Cannas, P. Cano Megias, M. Cappelli, A. Cardinali, S. Carli, D. Carnevale, M. Carpita, P. Carvalho, A. Casolari, F. Casson, C. Castaldo, R. Castro, A. Cathey, F. Causa, J. Cavalier, M. Cavedon, J. Cazabonne, M. Cecconello, L. Ceelen, A. Celora, J. Cerovsky, C. Challis, R. Chandra, B. Chapman-Oplopoiou, O. Chellai, X. Chen, M. Chernyshova, J. Chlum, P. Chmielewski, A. Chomiczewska, F. Cichocki, R. Cicioni, A. Cioffi, G. Ciraolo, S. Ciufo, A. Ciurlino, A. Civit, F. Clairet, A. Clod, S. Coda, R. Coelho, I. Coffey, L. Colas, S. Conroy, C. Contre, N. Conway, R. Coosemans, L. Cordaro, M. Cornelissen, Y. Corre, Š. Costea, X. Courtois, T. Craciunescu, G. Croci, K. Crombe, D.J. Cruz Zabala, F. Cursi, M. Czarski, T. Czarski, F.A. D’Isa, M. Dalla Rosa, M. Damiano, M. De Angeli, E. de la Cal, E. De La Luna, G. De Masi, C. De Piccoli, J. De Rycke, G. De Tommasi, J. Decker, R. Dejarnac, W. Dekeyser, D. Del Sarto, E. Delabie, J. Denis, G. Derks, C. Desgranges, E. Devlaminck, P. Devynck, L.E. di Grazia, C. Di Troia, M. Dicorato, M. Diez, V. Dimitriou, M. Dimitrova, T. Dittmar, L. Dittrich, D. Grekov, M. Dreval, C. Dritselis, S. Dubbioso, L. Dubus, R. Ducker, H. Dudding, R. Dumont, P. Dumortier, D. Dunai, M. Dunne, A. Durif, G. Durr-Legoupil-Nicoud, B. Duval, R. Dux, F. Ebrahimi, L. Edes, A. Ekedahl, S. Elmore, E. Emanuelli, G. Ericsson, F. Eriksson, J. Eriksson, B. Eriksson, D. Ernst, B. Esposito, E. Fable, M. Faitsch, D. Fajardo, N. Fakhrayi Mofrad, G.L. Falchetto, A. Fanni, N. Fedorczak, J. Ferreira, N. Ferron, L. Fevre, O. Fevrier, O. Ficker, A. Field, L. Figini, A. Figueiredo, P. Figueiredo, A. Fil, F. Fiorenza, D. Fiorucci, M. Firdaouss, R. Fischer, M. Fitzgerald, J. Flanagan, L. Fleury, T. Fonghetti, J.M. Fontdecaba Climent, P. Forestier-Colleoni, A. Frank, E. Fransson, L. Frassinetti, D. Frattolillo, D. Frigione, S.L. Fugazza, S. Futatani, S. Gabriellini, G. Galatola Teka, K. Galazka, J. Galdon-Quiroga, S. Galeani, D. Gallart, A. Gallo, C. Galperti, M. Gambrioli, S. Garavaglia, S. Garcia Herreros, M. Garcia Munoz, J.L. Gardarein, L. Garzotti, J. Gaspar, R. Gatto, P. Gaudio, E. Gauthier, M. Gelfusa, J. Gerardin, S. Gerasimov, G. Gervasini, E. Geulin, Z. Ghani, F.M. Ghezzi, L. Gil, A. Gillgren, E. Giovannozzi, C. Giroud, T. Gleiter, M. Gobbin, V. Goloborodko, J. Gonzalez-Martin, G. Gorini, D. Gossard, M. Grandin, G. Granucci, G. Grassler, G. Grenfell, M. Griener, W. Gromelski, M. Groth, O. Grover, M. Gruca, N. Grzybicka, A. Gude, C. Guillemaut, A. Guillevic, S. Guinchard, R. Guirlet, J. Gunn, T. Gyergyek, L. Hagg, P. Halldestam, C. Ham, D. Hamm, J. Harrison, E. Hasan-Toneva, N. Hawkes, S. Hegedus, P. Heinrich, C. Heiß, S. Henderson, P. Hennequin, C. Hernandez, J. Hillairet, A. Hjalmarsson, J. Hobirk, E. Hodille, R. Hojlund, M. Hölzl, M. Hoppe, J. Horacek, N. Horsten, A. Houben, J. Hromadka, Q. Hu, J. Hua, Z. Huang, A. Huart, A. Hubbard, A. Huber, P. Huynh, M. Iafrati, V. Igochine, F. Imbeaux, P. Innocente, N. Isernia, H. Isliker, V. Ivanov, P. Ivanova, I. Ivanova Stanik, S. Jachmich, P. Jacquet, M. Jagielski, L. Jansen, A. Jansen van Vuuren, A. Jardin, A. Jardin, H. Järleblad, A. Järvinen, F. Jaulmes, I. Jepu, M. Jimenez Comez, D. Jordan, J. Bryant, D. Kabirov, S. Kachkanov, J. Kalis, A. Kallenbach, J. Karhunen, A.N. Karpushov, E. Kaselouris, S. Kasilov, Y. Kazakov, P.V. Kazantzidis, H.T. Kim, D. King, V. Kiptily, A. Kirjasuo, A. Kirk, K. Kirov, A. Kirschner, A. Kit, T. Kiviniemi, A. Knieps, S. Kobussen, G. Kocsis, L. Kogan, J. Kolsen de Wit, Y. Kominis, M. Komm, M. Kong, B. Kool, S.B. Korsholm, D. Kos, M. Koubiti, J. Kovačič, Y. Kovtun, E. Kowalska-Strzeciwilk, K. Krieger, D. Kropackova, O. Krutkin, I. Kudashev, O. Kudlacek, H. Kuivasniemi, Y. Kulyk, U. Kumar, H. Kumpulainen, R. Kwiatkowski, M. La Matina, M. Ladygina, A. Lafay, L. Laguardia, P. Lainer, V. Laporta, M.R. Larsen, K. Lawson, M.Y.K. Lee, N. Lemoine, F. Lengyel, M. Lennholm, C. Leoni, E. Lerche, N. Leuthold, X. Li, Y.C. Liang, Y. Liang, J. Likonen, K. Lim, X. Litaudon, E. Litherland-Smith, G. Lo-Cascio, T. Loarer, L. Lobko, B. Lomanowski, J. Lombardo, N. Lonigro, R. Lorenzini, T. Lunt, J. Macdonald, R. Mackenbach, E. Macusova, R. Mäenpää, P. Maget, C. Maggi, S. Malec, J. Malinak, K. Malinowski, P. Manas, D. Mancini, P. Mantica, M. Mantsinen, M. Maraschek, G. Marcer, C. Marchetto, S. Marchioni, A. Mariani, M. Marin, D. Maris, M. Markl, T. Markovic, L. Marrelli, C. Martin, S. Masillo, M. Maslov, R. Masocco, V. Masson, M. Mattei, S. Mattogno, D. Matveev, M.L. Mayoral, D. Mazon, D. Mazur, S. Mazzi, K. McKay, A. Andrew, A. Mele, V. Menkovski, S. Menmuir, J. Merchand, A. Merle, K. Mikszuta-Michalik, D. Milanesio, L. Milia, I.G. Miron, R. Mirowski, S. Misdanitis, R. Mishra, J. Mitchell, R. Mitteau, V. Mitterauer, D. Moiraf, V. Moiseenko, P. Molina, S. Molisani, F. Mombelli, I. Monakhov, C. Monti, A. Montisci, J. Morales, D. Morbey, A. Moreau, P. Moreau, R. Morgan, J. Moritz, A. Moro, D. Moulton, A. Murari, A. Muraro, K. Murray, O. Myatra, D. Mykytchuk, F. Nabais, Y. Nakeva, F. Napoli, M.F. Nave, A. Nelson, A.H. Nielsen, S.K. Nielsen, A. Niemelä, M. Nocente, R. Nouailletas, S. Nowak, H. Nyström, M. O’Mullane, R. Ochoukov, S. Olasz, C. Olde, J. Oliver, J. Ongena, J.M. Ordonez Jimenez, A. Orduna Martinez, L. Orlandi, C. Orrico, F.P. Orsitto, R. Osawa, A. Osipov, R. Otin, J.J. Palacios Roman, D.I. Palade, O. Pan, N. Panadero, A. Panera Alvarez, P. Papagiannis, G. Papp, V. Parail, A. Parrott, K. Paschalidis, M. Passoni, F. Pastore, B. Patel, A. Patel, A.H. Patel, A. Pau, E. Pawelec, M. Pedrini, G. Pelka, E. Peluso, A. Perek, J. Gonzalez-Martin, J. Perez Gonzalez, C. Perez Von Thun, F. Pesamosca, M. Peterka, K. Petersen, P. Petersson, L. Pigatto, L. Piron, C. Piron, A. Pironti, F. Pisano, V. Plyusnin, M. Podesta, A. Podolnik, Y. Poels, G. Pokol, J. Poley, L.M. Pomarjanschi, M. Poradzinski, L. Porte, C. Possieri, I. Predebon, G. Pucella, F. Puentes del Pozo, M.J. Pueschel, P. Puglia, T. Pütterich, V. Quadri, M. Rabinski, R. Ragona, M. Rasinski, J. Rasmussen, G. Ratta, S. Ratynskaia, T. Ravensbergen, M. Rebai, D. Rees, D. Refy, M. Regine, H. Reimerdes, M. Reisner, B. Reman, P. Ren, C. Reux, A. Reyner-Vinolas, D. Ricci, M. Richou, S. Rienäcker, D. Rigamonti, F. Rigollet, V.P. Rikala, F. Rimini, N. Rispoli, N. Rivals, A. Rodriguez Gonzalez, J.F. Rivero-Rodriguez, T. Rizzi, C. Roach, M.M. Robaldo, S. Rode, P. Rodrigues, V. Rohde, J. Romazanov, R. Rossi, G. Rubino, J. Rueda-Rueda, F. Ruffini, P. Ryan, D. Ryan, J. Rzadkiewicz, S. Saarelma, S. Saari, R. Sabot, M. Sackers, D. Sales de Oliveira, M. Salewski, A. Salmi, C. Salvia, L. Sanchis, J. Santos, S. Sartorello, O. Sauter, R. Scannell, J. Schatzlmayr, L. Schiesko, B.S. Schmidt, P.A. Schneider, N. Schoonheere, K. Schutjes, L. Scotti, F. Scotti, J. Seidl, L. Senni, G. Sergienko, S. Setzu, D. Sgrelli, S. Sharapov, R. Sharma, U. Sheikh, G. Sias, B. Sieglin, S. Silburn, C. Silva, A. Silva, D. Silvagni, L. Simons, J. Simpson, L. Singh, S. Sipilä, M.M. Skyllas, E.R. Solano, M. Sos, C. Sozzi, S. Spagnolo, C. Srinivasan, A. Stagni, Z. Štancar, G. Stankunas, D. Stieglitz, J. Stobbs, P. Strand, F. Subba, H. Sun, G.Y. Sun, H. Sun, W. Suttrop, J.P. Svantner, J. Svoboda, D. Svorc, G. Szepesi, T. Szepesi, F. Taccogna, R. Takacs, T. Tala, P. Tamain, M. Tan, W. Tang, M. Tardocchi, D. Taylor, G. Telesca, A. Tenaglia, D. Terranova, D. Testa, C. Theiler, E. Tholerus, B. Thomas, A. Thrysoe, Q. Tichit, A. Titarenko, P. Tolias, E. Tomasina, M. Tomes, A. Tonel, E. Tonello, A. Tookey, B. Tosto, E. Trier, J.W. Tumbokon, M. Tunkl, A. Uccello, M. Ugoletti, P. Ulbl, G. Urbanczyk, A. Valentini, M. Valovic, M. van Berkel, D. Van Eester, G. Van Parys, M. van Rossem, B. Vanovac, H.P. Varadarajan, S. Vartanian, M. Vavrik, M. Vaz, J. Vega, L. Velarde Gallardo, C. Venturini, M. Veranda, T. Verdier, G. Verdoolaege, K. Verhaegh, L. Vermare, A. Vesa, J. Vicente, E. Viezzer, L. Vignitchouk, F. Villone, C. Vincent, B. Vincent, P. Vincenzi, J. Vinklárek, P. Virtanen, I. Voitsekhovitch, L. Votta, M. Vulcano, T. Vuoriheimo, E. Wang, Y. Wang, C. Wang, Y. Wang, T. Wauters, H. Weisen, N. Wendler, A. Widdowson, S. Wiesen, M. Wiesenberger, T. Wijkamp, M. Willensdorfer, M. Winkel, A. Wojenski, E. Wolfrum, H. Wu, I. Wyss, Q. Xia, L. Xiang, P. Xie, S. Xu, D. Yadykin, X. Yan, Y. Yang, H. Yang, K. Ye, R. Zagorski, P. Zanca, K.D. Zastrow, Y. Zayachuk, J. Zebrowski, P. Zenz, M. Zerbini, P. Zestanakis, H. Zhang, Y. Zhang, W. Zholobenko, B. Zimmermann, A. Zito, M. Zlobinski, V.K. Zotta, M. Zuin, M. Zurita +777 moredoaj +1 more sourcePeripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini +8 morewiley +1 more source
