Results 61 to 70 of about 1,326,556 (316)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Assessing Disruptions in Pharmaceutical Supply Chains: A Qualitative Study of Resilience and Risks in the South African Context [PDF]

Journal of Economic and Social Development (Varaždin)
This study evaluates the disruptions in South African pharmaceutical supply chains, focusing on resilience mechanisms and risk factors essential for maintaining continuity and efficiency amidst various disruptions. It leverages a comprehensive literature
Blessing Takawira, David Pooe, Alexander Samuels   +2 more
doaj  

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Transgenic Algorithm Applied to the Job Shop Rescheduling Problem

Ingeniería
Context: Job sequencing has been approached from a static perspective, without considering the occurrence of unexpected events that might require modifying the schedule, thereby affecting its performance measures.
Néstor Andrés Beltrán-Bernal, José Ignacio Rodríguez-Molano, Diego Ernesto Mendoza-Patiño   +2 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Disrupting Education: Which between technological innovations and the ‘incredulity towards metanarratives’ is disrupting education?

Recoletos Multidisciplinary Research Journal, 2015
According to Clayton Christensen’s Disruptive Innovation Theory, upstarts eat up market share often with innovative and more affordable products and soon become the new market leader.
Jose D. Velez Jr.
doaj   +1 more source

Proactive Planning of Project Team Members’ Competences

Foundations of Management, 2020
Among the many factors that cause project delays or cancellations are disruptions, that is, unforeseen events occurring during the implementation of a project, which postpone or interrupt the performance of project activities.
Szwarc Eryk, Wikarek Jarosław
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Methods for mitigating disruptions in complex supply chain structures: a systematic literature review

International Journal of Production Research, 2020
Supply chain risk management is extremely important for the success of a company. Due to the increasing complexity of supply chains, avoiding and mitigating the effects of disruptions is very challenging. This article presents the results of a systematic
Tobias Bier, A. Lange, C. Glock
semanticscholar   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source