Results 61 to 70 of about 170,017 (236)

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Exploring and describing management action for the pursuit of disruptive innovation [PDF]

, 2004
Disruptive Innovation as a theory is often misunderstood and as a term it tacks clear definition. Moreover, there is an absence in existing research of a coherent framework to explain the qualitative factors that management practitioners face when ...
Thomond, Peter Nicholas
core   +3 more sources

Using Disruptive Coloration and Ultraviolet Light to Prevent Barnacle Settlement [PDF]

, 2020
Biofouling or the accumulation of unwanted micro and macro organisms is problematic for the shipping industry. Barnacles are one of the most abundant fouling organisms and their settlement on ship hulls can result in costly damage.
Richard, Kailey Nicole
core   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

What Did Disruptive Students Say They Wanted From Their Classes? A Survey of Student Voices [PDF]

, 2015
This paper draws on data from over 60 students in order to find out how disruptive students viewed disrupted classes. The purpose of this research was to prepare training for tutors who were finding disruptive classes difficult to teach.
Lebor, Merv, Merv Lebor
core   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Facial skin coloration affects perceived health of human faces [PDF]

, 2009
I stephen was funded by a BBSRC Studentship. M Stirrat was funded by an EPSRC Studentship.Numerous researchers have examined the effects of skin condition, including texture and color, on the perception of health, age, and attractiveness in human faces ...
Stirrat, Michael Robert, David I. Perrett, Miriam J. Law Smith, Law Smith, Miriam Jane, Stephen, Ian David, Ian D. Stephen, Michael R. Stirrat, Perrett, David Ian, Stephen, Ian D., Perrett, David I., Law Smith, Miriam J., Stirrat, Michael R., Perrett, David Ian; id_orcid   +12 more
core   +1 more source

Light at night disrupts nocturnal rest and elevates glucocorticoids at cool color temperatures [PDF]

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, 2018
AbstractNighttime light pollution is quickly becoming a pervasive, global concern. Since the invention and proliferation of light‐emitting diodes (LED), it has become common for consumers to select from a range of color temperatures of light with varying spectra. Yet, the biological impacts of these different spectra on organisms remain unclear.
Valentina J. Alaasam, Richard Duncan, Stefania Casagrande, Scott Davies, Abhijaat Sidher, Brett Seymoure, Yantao Shen, Yong Zhang, Jenny Q. Ouyang   +8 more
openaire   +3 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source