Results 271 to 280 of about 479,019 (353)

Surgical Challenges in Papillary Thyroid Cancer Patient With Kartagener's Syndrome: A Case Report. [PDF]

Clin Case Rep
Huang J, Zhao T, Wei M.
europepmc   +1 more source

Halofuginone is a Molecular Glue Degrader of Integrin β4

Advanced Science, EarlyView.
Integrin β4 overexpression is linked to aggressive tumors and poor prognosis, but targeted therapies are lacking. We identified halofuginone (HF) as a molecular glue degrader that promotes integrin β4 degradation via the CRL4BWDR18 E3 ligase. HF suppresses tumor progression in vitro and in vivo, offering a new strategy for targeting oncogenic ...
Wei Gong, Di Yang, Junrui Tian, Yufei Chai, Tiantian Yu, Qingnan Wu, Yan Wang, Weimin Zhang, Qimin Zhan   +8 more
wiley   +1 more source

Prevalence and Prognostic Value of Mediastinal Lymph Node Dissection in Pulmonary Metastasectomy: A Retrospective Single-Center Analysis. [PDF]

Thorac Cancer
Galata C, Schulz J, Grifone L, Zapata Bonila SA, Kindler T, Athanassiadi K, Roessner E, Karampinis I.   +7 more
europepmc   +1 more source

Download the PDF of the Entire Issue: Jefferson Surgical Solutions vol. 3, issue 2, Fall 2008 [PDF]

, 2008

core   +1 more source

Mechanostimulatory Cues Determine Intestinal Fibroblast Fate and Profibrotic Remodeling in a Physiodynamic Human Gut‐on‐a‐Chip

Advanced Science, EarlyView.
A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min, Nam Than, Yong Cheol Shin, Elif G. Ertugral, Chandrasekhar R. Kothapalli, Olumuyiwa Awoniyi, Hyun Jung Kim   +6 more
wiley   +1 more source

A Case of Robot-Assisted Ileocecal Resection for Ascending Colon Cancer with Ileocolic Vein Flowing into the Jejunal Vein: Case Report. [PDF]

Surg Case Rep
Kobayashi K, Paku M, Takahashi H, Honda T, Sakamoto N, Hukumori K, Watsapol J, Iwami Y, Ishikawa S, Iwamoto K, Takaichi S, Ohashi T, Nakahara Y, Murakami K, Asaoka T, Omori T, Takemasa I.   +16 more
europepmc   +1 more source

CRP Deficiency Rescues Periodontitis‐Induced Hippocampal Neurogenesis Impairment by Suppressing OPC‐Derived BMP4 Signaling in Rats

Advanced Science, EarlyView.
Chronic periodontitis elevates circulating CRP, which enters the hippocampus to upregulate BMP4 in oligodendrocyte precursor cells (OPCs), thereby impairing neurogenesis and inducing anxiety/depression‐like behaviors in rats. Counteracting this pathway, CRP deficiency helps confer functional resilience to OPCs.
Lingjie Li, Ping Deng, Siyu Hou, Xianbo Xia, Wei Zhao, Xingyu Zhu, Yang Zhang, Chao Wang, Ling Xu, Jinlin Song   +9 more
wiley   +1 more source

Minimally Invasive Cardiac Surgery for Spontaneous Coronary Artery Dissection. [PDF]

Surg Case Rep
Usui R, Uchida W, Yazawa T, Usui A, Mutuga M.   +4 more
europepmc   +1 more source

A Testis‐Specific Aralkylamine N‐Acetyltransferase Regulates Dimorphic Sperm Function and Male Fertility in Moths

Advanced Science, EarlyView.
We identify a Lepidoptera‐conserved testis‐specific arylalkylamine N‐acetyltransferase (LTNAT) that governs male moth fertility via a novel mechanism. LTNAT loss disrupts eupyrene sperm mitochondrial derivatives and impairs apyrene sperm motility, offering a safe molecular target for innovative pesticides and genetic pest control.
Hao Sun, Peng‐Yi Huang, Zhi‐Ruo Zhang, Cong‐Fen Gao, Subba Reddy Palli, Shun‐Fan Wu   +5 more
wiley   +1 more source