Results 31 to 40 of about 432,748 (214)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Master of Science [PDF]

, 2010
thesisCadaver dissection has been a fundamental part of the education of medical students for hundreds of years. Since the 16th century, dissection has been touted as the premier method for educating doctors in training on human anatomy.
Skinner, Michelle D.
core  

Spontaneous Coronary Artery Dissection: A Case Series of 9 Patients With Literature Review. [PDF]

, 2018
Spontaneous coronary artery dissection is an increasingly recognized nonatherosclerotic cause of acute coronary syndrome. Reports regarding the prognosis and natural history of this disease are limited.
Ali, Nouman Safdar, Anjum, Reema, Ghani, MD, Ali Raza, Hashmi, Arsalan Talib, Inayat, Faisal, Klugherz, Bruce D., Riaz, Iqra, Viray, Michael, Virk, Hafeez Ul Hassan   +8 more
core   +2 more sources

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Crack phase-field modeling of anisotropic rupture in fibrous soft tissues [PDF]

, 2017
The estimation of rupture in fibrous soft tissues has emerged as a central task in medical monitoring and risk assessment of diseases such as aortic dissection and aneurysms.
Dal, H., Gültekin, O., Holzapfel, G.A.
core  

Virtual reality training and assessment in laparoscopic rectum surgery [PDF]

, 2015
Background: Virtual-reality (VR) based simulation techniques offer an efficient and low cost alternative to conventional surgery training. This article describes a VR training and assessment system in laparoscopic rectum surgery.
Aggarwal, Alastrué, Ali, Antman, Atkinson, Basdogan, Bathe, Chang, Chang, Chang, Chih-Hao, Choi, Chuong, Cotin, Francone, Ganovelli, Grantcharov, Gurusamy, Heng, Hong, Hájek, Lin, Lu, Maciel, Mollemans, Pan, Pan, Picinbono, Prime, Wu, Zhao   +30 more
core   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Dissection of the ascending thoracic aorta as a complication of percutaneous coronary intervention [PDF]

, 2008
Acute aortic dissection is a medical emergency with high morbidity and mortality requiring emergent diagnosis and therapy. A 79-year-old woman with acute aortic dissection due to percutaneous coronary intervention was presented.
Akdemir, Ramazan, Arinc, Huseyin, Gunduz, Huseyin, Uyan, Cihangir   +3 more
core   +2 more sources

CINs of the cytoplasm: dissecting dsRNA signaling in chromosomal instability

Molecular Oncology, EarlyView.
Micronuclei, formed during cell division in chromosomal instability settings, rupture and lead to the accumulation of immunogenic double‐stranded RNA in the cytoplasm, activating MAVS‐dependent interferon signaling and innate antitumor immunity.
Aglaia Skolariki, Rose L. Jady‐Clark, Eileen E. Parkes   +2 more
wiley   +1 more source

Mandatory multidisciplinary approach for the evaluation of the lymph node status in rectal cancer [PDF]

, 2018
Colorectal cancer is the third most frequently reported malignancy and also the third leading cancer-related cause of death worldwide. Lymph node evaluation, both preoperatively and postoperatively, represents an important aspect of the diagnosis and ...
Ciorbagiu, Mihai C., Diaconescu, Marian, Mirea, Cecil S., Moraru, Emil, Obleaga, Cosmin V., Vilcea, Ionica D.   +5 more
core   +7 more sources