Results 71 to 80 of about 476,666 (340)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Accessory slip of fibularis tertius to extensor digitorum longus — an unreported variant

Folia Morphologica
The fibularis tertius (FT) is one of three muscles which constitute the anterior compartment of the leg. The anatomical variants of this muscle usually pertain to its origins, number of final tendons or points, and shapes of insertions. In the particular
Andrzej Węgiel, Nicol Zielinska, Krystian Maślanka, Bartosz Gonera, Konrad Kurtys, Łukasz Olewnik   +5 more
doaj   +1 more source

Axillary lymph node recurrence following wire‐directed sentinel lymph node dissection for breast cancer patients with biopsy‐proven axillary metastases prior to neoadjuvant chemotherapy at a safety net medical center [PDF]

, 2023
Rachel E. Sargent, Emily Siegel, Fumito Ito, Katherine Kramme, Elizabeth Kraft, Vera Hendrix, Azadeh A. Carr, Maria Nelson, Shelly X. Bian, Priya Jayachandran, Stephen Sener   +10 more
openalex   +1 more source

Assessment in anatomy [PDF]

, 2015
From an educational perspective, a very important problem is that of assessment, for establishing competency and as selection criterion for different professional purposes. Among the issues to be addressed are the methods of assessment and/or the type of
Brenner, Erich, Chirculescu, Andy R M, Reblet, Concepción, Smith, Claire   +3 more
core   +1 more source

Propagation-based phase-contrast synchrotron imaging of aortic dissection in mice : from individual elastic lamella to 3D analysis [PDF]

, 2018
In order to show the advantage and potential of propagation-based phase-contrast synchrotron imaging in vascular pathology research, we analyzed aortic medial ruptures in BAPN/AngII-infused mice, a mouse model for aortic dissection. Ascending and thoraco-
Aoki, Hiroki, Aslanidou, Lydia, De Backer, Julie, Logghe, Gerlinde, Segers, Patrick, Stampanoni, Marco, Stergiopulos, Nikolaos, Trachet, Bram, Villaneuva-Perez, Pablo   +8 more
core   +3 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Role of initial medical treatment and effectiveness of thoracic endovascular aortic repair for acute type A aortic dissection with thrombosed false lumen [PDF]

, 2023
Kenta Masada, Kento Shinzato, Shigeki Koizumi, Koki Yokawa, Mio Kasai, Yosuke Inoue, Yoshimasa Seike, Hiroaki Sasaki, Hitoshi Matsuda   +8 more
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Focal Spot, Fall/Winter 2000 [PDF]

, 2000
https://digitalcommons.wustl.edu/focal_spot_archives/1086/thumbnail ...

core   +1 more source

A task and performance analysis of endoscopic submucosal dissection (ESD) surgery [PDF]

, 2019
BACKGROUND: ESD is an endoscopic technique for en bloc resection of gastrointestinal lesions. ESD is a widely-used in Japan and throughout Asia, but not as prevalent in Europe or the US.
Bayrak, Coskun, Cetinsaya, Berk, Cohen, Jonah, De, Suvranu, Demirel, Doga, Gromski, Mark A., Halic, Tansel, Hegde, Sudeep, Jackson, Cullen, Jones, Daniel B., Lee, Sangrock, Sawhney, Mandeep, Stavropoulos, Stavros N., Xia, Zhaohui   +13 more
core   +1 more source