Results 71 to 80 of about 288,431 (247)

Purkinje Cell Loss in Essential Tremor: Collective Data From 215 Brains Over a 21‐Year Period

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Essential tremor is a highly prevalent movement disorder. Pathological changes observed in essential tremor cerebella center around Purkinje cells and neighboring neuronal populations. Postmortem studies have variably, but not always, shown reduced Purkinje cell counts in essential tremor compared to controls.
Chloë A. Kerridge   +4 more
wiley   +1 more source

Growth Differentiation Factor 15 Elevation in the Central Nervous System Is Associated With Failure to Thrive in Alexander Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Alexander disease (AxD) is a severe neurodegenerative disorder caused by gain‐of‐function mutations in the gene for GFAP, which lead to protein aggregation and a primary astrocytopathy. Symptoms vary, but failure to thrive (FTT) and frequent emesis are common and cause significant morbidity. Here we investigate GDF15, a member of the
Tracy L. Hagemann   +6 more
wiley   +1 more source

Copy Number Variants and Their Association With Intracerebral Hemorrhage Risk: A Case–Control Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Intracerebral Hemorrhage (ICH) is a leading cause of morbidity and mortality worldwide and lacks effective therapeutic interventions. Despite previous studies, the genetic underpinnings of ICH remain poorly understood. We sought to investigate the role of copy number variants (CNVs) in ICH pathophysiology to identify novel ...
Savvina Prapiadou   +12 more
wiley   +1 more source

Exploring patients’ profiles associated with the resolution of acute calcium pyrophosphate arthritis treatedwith colchicine and prednisone: post hoc analysis of a randomized controlled trial

open access: yesArthritis Care &Research, Accepted Article.
Objective The objective was to identify factors determining acute arthritis resolution and safety with colchicine and prednisone in acute calcium pyrophosphate (CPP) crystal arthritis. Methods We conducted a post hoc analysis of the COLCHICORT trial, which compared colchicine and prednisone for the treatment of acute CPP crystal arthritis, using a ...
Tristan Pascart   +14 more
wiley   +1 more source

The morphological variability of the pelvic girdle muscles: a potential trap during ultrasound

open access: yesFolia Morphologica
BACKGROUND: The muscles present in the pelvic girdle compartment demonstrate clinically significant anatomical variation regarding both their site of attachment and additions, such as accessory heads, muscles, or tendinous slips. Many of those variations
Marta Pośnik   +3 more
doaj   +1 more source

Ultrasound compared to Computed Tomography in identifying thoracic aortic aneurysms in patients with Giant Cell Arteritis

open access: yesArthritis Care &Research, Accepted Article.
Objectives The objectives of this study were to evaluate the correlation and agreement between ultrasound and computed tomography (CT) in measuring ascending aorta diameter in patients with giant cell arteritis (GCA) and to investigate the development of new ascending aortic aneurysms in patients with newly diagnosed GCA. Methods To achieve the primary
Anne C Bull Haaversen   +4 more
wiley   +1 more source

Deltoid muscle: a proposed classification system on human foetuses

open access: yesFolia Morphologica
BACKGROUND: The deltoid muscle originates from the spine of the scapula, the lateral border of the acromion, and the lateral third of the clavicle. It inserts on the deltoid tuberosity.
Krzysztof Koptas   +4 more
doaj   +1 more source

Is medical therapy still the optimal treatment strategy for patients with acute type B aortic dissections? [PDF]

open access: bronze, 2002
Juan P. Umaña   +10 more
openalex   +1 more source

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