Results 51 to 60 of about 4,672 (301)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Dissimilation as Local Conjunction [PDF]
, 1997 While the OCP has been an essential tool in describing the distribution of phonological features, a fundamental problem arises when it is applied to the analysis of dissimilation processes and segmental cooccurrence restrictions. Such phenomena typically
core
Evidence for perceptual hypercorrection in American r-dissimilation: A pilot study [PDF]
, 2019 We tested Ohala\u27s (1993) theory that dissimilation results from perceptual hypercorrection for assimilation. We created nonce words by splicing syllables containing /r/ to continuations that either did or did not contain another /r/.
Orellana, Irene +4 more
core +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
La legge di Grassmann in greco come regola morfologica
Atti del Sodalizio Glottologico Milanese, 2019 Grassmann’s Law in Greek as morphological rule. Grassmann’s Law ‒ the phonetic change by virtue of which in an original diaspirate root a (regressive) dissimilation process takes place ‒ is generally regarded as working in reduplicated verbal forms, see ...
Alessandro De Angelis
doaj +1 more source
Phonological Processes according to SÄ«bawayh [PDF]
دراسات في اللغة العربيّة وآدابها, 2010 This article inbestigates some of the phonological processes which are mentioned by SÄ«bawayh . Phonological Processes include two types: Phonetic and stylistic .
Ibrahim Mohammad al-Bāb
doaj +1 more source
Aspiration 'dissimilation' in Tangkhul Naga prefixation [PDF]
, 2017 In Tangkhul Naga, obstruent-initial prefixes are strictly unaspirated if followed by any stem-initial obstruent, and aspirated before stem-initial sonorants (Arokianathan 1987, Mortensen 2003, Shosted 2007).
Deepthi Gopal, Gopal, Deepthi
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Dissimilation by surface correspondence in Aghem velarized diphthongs [PDF]
, 2014 Aghem exhibits a static co-occurrence restriction involving an intrusive velar segment present in two of the language\u27s falling diphthongs. I provide a brief descriptive overview of these unusual phonetic structures and an Agreement by Correspondence (
Faytak, Matthew
core +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source