Results 31 to 40 of about 27,998 (260)
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
BuildingsFatigue failure in asphalt pavements, caused by continuous loading, primarily occurs at the interface between the asphalt binder and the aggregate (adhesive failure) or within the asphalt binder itself (cohesive failure).
Huayang Yu +3 more
doaj +1 more source
Characteristics of energy storage and dissipation of coal under one‐time cyclic load
Energy Science & Engineering, 2020 Energy is an important research parameter in rock mechanics. To explore the law of energy evolution of coal, a one‐time loading and unloading test under uniaxial compression was conducted on coal taken from four different coal mines.
Kang Peng +6 more
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Fracture and Structural Integrity, 2014 The energy dissipated to the surroundings as heat in a unit volume of material per cycle, Q, was recently proposed by the authors as fatigue damage index and it was successfully applied to correlate fatigue data obtained by carrying out fully reversed ...
G. Meneghetti, M. Ricotta, B. Atzori
doaj
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Gaoya wuli xuebaoIn order to study the influence of hoop stress on the energy evolution in the process of rockburst catastrophe, a new true triaxial rockburst test system was used to carry out the rockburst simulation test of single-side rapid unloading, three-five-side ...
Huaxu ZHANG +4 more
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In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Topological sensitivity analysis of a time-dependent nonlinear problem
Boundary Value Problems, 2019 We are interested in the optimization of the pipe shape allowing minimization of the dissipated energy in time-dependent Navier–Stokes Darcy flow. The used technique is based on the topological gradient method.
Mohamed Abdelwahed +3 more
doaj +1 more source