Results 131 to 140 of about 12,800 (285)

Clinical Trial: Efficacy and Safety of Velusetrag in Chronic Intestinal Pseudo‐Obstruction: A Randomized, Phase 2, Placebo‐Controlled, Crossover, Multiple (n = 1), Proof‐of‐Concept Study

Neurogastroenterology &Motility, Volume 38, Issue 1, January 2026.
This phase 2 proof‐of‐concept trial evaluated the efficacy and safety of velusetrag in patients with chronic intestinal pseudo‐obstruction. Velusetrag treatment was generally well tolerated and was associated with improved symptoms and a reduction in pseudo‐obstructive episodes versus placebo, although these differences did not reach statistical ...
Carolina Malagelada, Roberto De Giorgio, Rosanna Francesca Cogliandro, Luis Alcalá‐González, Anna Costanzini, Valeria Scuderi, Sara Manzoni, Elena Pasquali, Jan Tack, Vincenzo Stanghellini   +9 more
wiley   +1 more source

Intestinal and Multivisceral Transplantation: Where We Stand Today

Pediatric Transplantation, Volume 30, Issue 1, January 2026.
ABSTRACT Intestinal and multivisceral transplantation has evolved from an experimental to a life‐saving procedure for children and adults with complications of gut failure (GF). Suboptimal long‐term outcomes of transplant elicit recent advances in surgical and medical gut rehabilitation along with the introduction of glucagon‐like peptide‐2 (GLP‐2 ...
Mohamed Maklad, Mohammed Osman, Mariam Ismail, Tetsuya Tajima, Kadakkal Radhakrishnan, Masato Fujiki   +5 more
wiley   +1 more source

Congenital Myopathy Due to RyR1 Gene Mutation in a Newborn Masquerading as a Consequence of Hypoxic-ischemic Encephalopathy

Indian Pediatrics Case Reports
Background: Congenital myopathies may be a cause of prolonged and persistent hypotonia and weakness in a newborn, which may be overlooked as a neurological consequence of hypoxic-ischemic encephalopathy.
Yamini Patial, Rohit Anand
doaj   +1 more source

Rituximab in the treatment of inflammatory myopathies: a review [PDF]

, 2017
Several uncontrolled studies have encouraged the use of rituximab (RTX) in patients with myositis. Unfortunately, the first placebo-phase trial to assess the efficacy of RTX in refractory myositis did not show a significant difference between the two ...
Fasano, S, Gordon, P, Hajji, R, Isenberg, DA, Loyo, E   +4 more
core  

Volitional exercise elicits physiological and molecular improvements in the severe D2.mdx mouse model of Duchenne muscular dystrophy

The Journal of Physiology, Volume 604, Issue 2, Page 849-867, 15 January 2026.
Abstract figure legend This study investigated the effects of volitional exercise on muscle health in the more severe D2.mdx model of Duchenne muscular dystrophy (DMD). We showed that 8–10 weeks of a relatively high volume of voluntary wheel running (VWR) in D2.mdx animals augmented select muscle mass and normalized ex vivo muscle force compared to ...
Stephanie R. Mattina, Sean Y. Ng, Andrew I. Mikhail, Derek W. Stouth, Cora E. Jornacion, Irena A. Rebalka, Thomas J. Hawke, Vladimir Ljubicic   +7 more
wiley   +1 more source

Piezo1 in intestinal smooth muscle cells: Emerging perspectives

The Journal of Physiology, Volume 604, Issue 1, Page 129-144, 1 January 2026.
Abstract figure legend Loss of Piezo1 in SMCs results in delayed gut transit, impaired small bowel contractility, and tissue alterations. But more critically, Piezo1 is shown to be intracellularly localized, highlighting important implications given the phenotype. Adapted from Bautista, G.M. et al.
Geoanna M. Bautista, L. Fernando Santana, Martin G. Martin   +2 more
wiley   +1 more source

Homozygosity and linkage disequilibrium mapping of autosomal recessive distal myopathy (Nonaka distal myopathy) [PDF]

, 2001
Tomoya Asaka, Ken Ikeuchi, Soichi Okino, Y. Takizawa, Ryouko Satake, Eishun Nitta, Koichiro Komai, K. Endo, S. Higuchi, Tatsuya Oyake, T Yoshimura, Akihito Suenaga, Eiichiro Uyama, Tatsuya Saito, M Konagaya, N Sunohara, Reiko Namba, Hiroshi Takada, K Honke, Masayoshi Nishina, Hajime Tanaka, M Shinagawa, Keiko Tanaka, A. Matsushima, Shoji Tsuji, Masaharu Takamori   +25 more
openalex   +1 more source

Late-onset distal myopathy, Markesbery-Griggs type [PDF]

, 2020
INSERM
openalex   +1 more source

Distal Myopathy [PDF]

Proceedings of the Royal Society of Medicine, 1913
openaire   +2 more sources

Reduction of UDP-N-acetylglucosamine 2-Epimerase/N-Acetylmannosamine Kinase Activity and Sialylation in Distal Myopathy with Rimmed Vacuoles [PDF]

, 2004
S. Noguchi, Yoko Keira, Kumiko Murayama, Megumu Ogawa, Masako Fujita, Genri Kawahara, Yasushi Oya, Masaoki Imazawa, Yu‐ichi Goto, Yukiko Hayashi, Ikuya Nonaka, Ichizo Nishino   +11 more
openalex   +1 more source