Results 261 to 270 of about 41,123 (303)

Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

open access: yesAdvanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou   +12 more
wiley   +1 more source

Fluoride varnish application and the temporal evolution of supragingival microbiota in children with differential caries risk. [PDF]

open access: yesJ Oral Microbiol
Liu F   +9 more
europepmc   +1 more source

An adaptive A-Star algorithm to handle blood transportation using UAVs. [PDF]

open access: yesSci Rep
Zaki C   +6 more
europepmc   +1 more source

An inequality involving the second largest and smallest eigenvalue of a distance-regular graph [PDF]

open access: yesLinear Algebra and Its Applications, 2011
For a distance-regular graph with second largest eigenvalue (resp., smallest eigenvalue) θ1 (resp., θD) we show that (θ1+1)(θD+1)⩽-b1 holds, where equality only holds when the diameter equals two.
Jack H Koolen, Jongyook Park
exaly   +4 more sources

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